Biography Henrique Alves

2000 – Degree in Biochemistry (5 years), University of Beira Interior, Covilhã, Portugal

2006 - Portuguese Foundation for Science and Technology (FCT) 2.5 years fellowship, Research Centre of Health Sciences, Covilhã, Portugal.

2007 - M.Sc. in Biochemistry, University of Beira Interior, Covilhã, Portugal

2009 - PhD in Neuroscience, Department of Neuromedical Genetics, The Netherlands Institute for Neuroscience (NIN), Royal Netherlands Academy of Arts and Sciences (KNAW), Amsterdam, The Netherlands

Publications Henrique Alves

Quintela, T., Gonçalves, I., Martinho A, Alves, C.H., Saraiva, M.J., Rocha, p., Santos, C.R.A. (2010) Progesterone Enhances Transthyretin Expression in the Rat Choroid Plexus In Vitro and In Vivo via Progesterone Receptor. Journal of Molecular Neuroscience. DOI: 10.1007/s12031-010-9398-x.

Alves, C.H., Gonçalves, I., Baltazar, G., Saraiva, M.J., Quintela, T., Santos, C.R.A. (2009) Androgen receptor is expressed in murine choroid plexuses and downregulated by 5-alfa-dihydrotestosterone in male and female mice. Journal of Molecular Neuroscience 38:41-9.

Quintela, T., Gonçalves, I., Baltazar, G., Alves, C.H., Saraiva, M.J., Santos, C.R.A. (2009) “17 β-estradiol induces transthyretin expression in murine choroid plexus via an intracellular oestrogen receptor dependent pathway”. Cellular and Molecular Neurobiology 29:475-83

Quintela, T., Alves, C.H., Gonçalves, I., Baltazar, G., Saraiva, M.J., Santos, C.R.A. (2008) “5α-dihydrotestosterone up-regulates transthyretin levels in mice and rat choroid plexus via an androgen receptor independent pathway”. Brain Research 1229:18-26.

Gonçalves, I., Alves, C.H., Quintela, T., Baltazar, G., Saraiva, M.J., Santos, C.R.A. (2008) "Transthyretin is up-regulated by sex hormones in mice liver". Molecular and Cellular Biochemistry 317:137-42.

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Personal Interests

Science was born from smart and creative questions. And, is growing to find a way to answer them. Once the answer is found many others will arise, keep feeding our thoughts, given us wings to dream and build new questions. What is the importance of the CRB2 in the retinal degeneration and it influences in others related proteins as: CRB1, CRB3, the MAGUK-family proteins, the PDZ-motif containing proteins, is one of these questions, and the main one present in my PhD project. To answer to this question we created Crb2 conditional knockout mice, using recombineering in bacterial artificial chromosomes and CRE/loxP technology. The conditional knockout mice were crossed with different transgenic mice expressing CRE. The generated Crb2 mutant mice are now ready to be characterized and to become a useful tool to study the functions of Crumbs proteins in retina and brain.

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