59. Park,B., Alves,C.H., Lundvig,D.M., Tanimoto,N., Beck,S.C., Huber,G., Richard,F., Klooster,J., Andlauer,T.F., Swindell,E.C., Jamrich,M., Le Bivic,A., Seeliger,M. and Wijnholds,J. (2011) PALS1 is essential for retinal pigment epithelium structure and neural retina stratification. J. Neurosci. 31:17230-17241.
58. Aartsen,W.M., van Cleef,K.W.R., Pellissier,L.P., Hoek,R.M., Vos,R.M., Blits,B., Ehlert,E.M.E., Balaggan,K.S., Ali,R.R., Verhaagen,J. and Wijnholds,J. (2010) GFAP-driven GFP expression in activated mouse Mueller glial cells aligning retinal blood vessels following intravitreal injection of AAV2/6 vectors. PLoS One 5:e12387.
57. Kim,S., Lehtinen,M.K., Sessa,A., Zappaterra,M.W., Cho,S.-H., Gonzalez,D., Boggan,B., Austin,C.A., Wijnholds,J., Gambello,M.J., Malicki,J., LaMantia,A.S., Broccoli,V., and Walsh,C.A. (2010). The apical complex couples cell fate and cell survival to cerebral cortical development. Neuron 66, 69-84.
56. Jaissle,G.B., May,C.A., van de Pavert,S.A., Wenzel,A., Claes-May,E., Giessle,A., Szurman,P., Wolfrum,U., Wijnholds,J., Fisher,M.D., Humphries,P., Seeliger,M.W. (2010). Bone spicule pigment formation in retinitis pigmentosa: insights from a mouse model. Graefes Arch Clin Exp Ophthalmol. 248: 1063-1070.
55. Fischer MD, Huber G, Beck SC, Tanimoto N, Muehlfriedel R, Fahl E, Grimm C, Wenzel A, Remé CE, van de Pavert SA, Wijnholds J, Pacal M, Bremner R, Seeliger MW. (2009). Noninvasive, in vivo assessment of mouse retinal structure using optical coherence tomography. PloS One 4:e7507.
54. Stöhr,H., Heisig,J.B., Milenkovic,V., Strauss,O., Benz,P.M., Aartsen,W.M., Wijnholds,J., Weber,B.H.F., Schulz, H.L. (2009). TMEM16B, a novel protein with calcium-dependent chloride channel activity, associates with a presynaptic protein complex in photoreceptor terminals. J. Neurosci. 29:6809-18.
53. Aartsen,W.M., Arsanto,J.-P., Chauvin,J.-P., Vos, R.M., Versteeg,I., Nunes Cardozo,B., Le Bivic,A., Wijnholds,J. (2009). PSD95β regulates plasma membrane Ca(2+) pump localization at the photoreceptor synapse. Mol. Cell. Neurosci.41:156-65.
52. de Wolf,C., Jansen,R., Yamaguchi,H., de Haas,M., van de Wetering,K., Schinkel,A., Wijnholds,J., Beijen,J., Borst,P. (2008). Contribution of the drug transporter ABCG2 (Breast Cancer Resistance Protein) to resistance against anti-cancer nucleosides. Mol. Cancer Ther., 7:3092-102.
51. Van de Pavert,S.A., Sanz Sanz,A., Aartsen,W.M., Vos,R.M., Versteeg,I., Beck,S.C., Klooster,J., Seeliger,M.W., and Wijnholds,J. (2007). Crb1 is a determinant of retinal apical Mueller glia cell features. Glia 55(14):1486-97.
50. Van de Pavert,S.A., Meuleman,J., Malysheva,A., Aartsen, W.M., Versteeg,I., Tonagel, T., Kamphuis, W., McCabe, C.J., Seeliger,M.W., and Wijnholds,J. (2007). A single amino acid substitution (Cys249Trp) in the sixth epidermal growth factor (EGF) domain of Crb1 causes retinal degeneration and deregulates expression of Pituitary tumor transforming gene 1 (Pttg1). J. Neurosci., 27:564-573.
49. de Wolf,C.J.F., Yamaguchi,H., van der Heijden,I., Wielinga,P.R., Hundscheid,S.L., Ono,N., Scheffer,G.L., de Haas,M., Schuetz,J.D., Wijnholds,J., and Borst,P. (2007). cGMP transport by vesicles from human and mouse erythrocytes. FEBS J., 274:439-450.
48. Gavarini,S., Becamel,C., Altier,C., Lory,P., Poncet,J., Wijnholds,J., Bockaert,J., and Marin,P. (2006). Opposite effects of PSD-95 and MPP3 PDZ proteins on serotonin 5-HT2C receptor desensitization and membrane stability. Mol. Biol. Cell, 17:4619-4631.
47. van Rossum,A.G., Aartsen,W.M., Meuleman,J., Klooster,J., Malysheva,A., Versteeg,I., Arsanto,J.-P., Le Bivic,A., and Wijnholds,J. (2006). Pals1/Mpp5 is required for correct localization of Crb1 at the sub-apical region in polarized Müller glia cells. Hum. Mol. Genet., 15 :2659-72.
46. Richard,M., Roepman,R., Aartsen,W.M., van Rossum,A.G., den Hollander,A.I., Knust,E., Wijnholds,J., and Cremers,F.P. (2006). Towards understanding CRUMBS function in retinal dystrophies. Hum. Mol. Genet., 15: R235-R243.
45. Aartsen,W.M., Kantardzhieva,A., Klooster, J., van Rossum,A.G. van de Pavert,S.A., Versteeg,I., Nunes Cardozo,B., Tonagel,F., Beck,S.C., Tanimoto,N., Seeliger,M.W., and Wijnholds,J. (2006). Mpp4 recruits Psd95 and Veli3 towards the photoreceptor synapse. Hum. Mol. Genet., 15:1291-302.
44. Kantardzhieva,A., Alexeeva,S., Versteeg,I., and Wijnholds,J. (2006). MPP3 is recruited to the MPP5 protein scaffold at the retinal outer limiting membrane. FEBS J. 273:1152-1165.
43. Minich,T., Riemer,J., Schultz,J.B., Wielinga,P., Wijnholds,J., and Dringen,R. (2006). The multidrug resistance protein 1 (Mrp1), but not Mrp5, mediates export of glutathione and glutathione disulfide from brain astrocytes. J. Neurochem., 97:373-384.
42. Zelcer,N., van de Wetering,K., de Waart,R., Scheffer,G., Marschall,H.U., Wielinga,P., Kuil,A., Kunne,C., Smith,A., van der Valk,M., Wijnholds,J., Oude Elferink,R. and Borst,P.(2006). Mice lacking Mrp3 (Abcc3) have normal bile salt transport, but display altered hepatic transport of endogenous glucuronides. J. Hepatology, 44:768-75.
41. Seeliger,M.W., Beck,S., Pereyra-Muñoz,N., Dangel,S., Tsai,J.-Y., Luhmann,U., van de Pavert,S., Wijnholds,J., Samardzija,M., Wenzel,A., Zrenner,E., Fahl,E., Tanimoto,N., Acar,N., and Tonagel,F. (2005). In vivo confocal imaging of the retina in animal models using scanning laser ophthalmoscopy. Vision Res. 45:3512-9.
40. Michel,D., Arsanto,J.P., Massey-Harroche,D., Beclin,C., Wijnholds,J., and Le Bivic,A. (2005). PATJ connects and stabilizes apical and lateral components of tight junctions in human intestinal cells. J.Cell Sci. 118:4049-57.
39. Kantardzhieva,A., Gosens,I., Alexeeva,S., Punte,I.M.,Versteeg,I., Krieger,E.,Neefjes-Mol,C.A., den Hollander,A.I., Letteboer,S.J.F., Klooster,J., Cremers,F.P.M., Roepman,R. and Wijnholds,J. (2005). MPP5 recruits MPP4 to the CRB1 complex in photoreceptors. Invest Ophthalmol Vis Sci 46:2192-201.
38. Wielinga,P., Hooijberg,J.H., Gunnarsdottir,G., Kathmann,I., Reid,R., Zelcer,N., van der Born,K., de Haas,M., van der Heijden,I., Kaspers,G., Wijnholds,J., Jansen,G., Peters,G., and Borst,P. (2005). The human multidrug resistance protein MRP5 transports folates and can mediate cellular resistance against antifolates. Cancer Research 65:4425-30.
37. Meuleman,J., van de Pavert,S., and Wijnholds,J. (2004). Crumbs homologue 1 in polarity and blindness. Biochem. Soc. Trans., 32, 828-830.
36. van de Pavert,S., Kantardzhieva,A., Malysheva,A., Meuleman,J., Versteeg,I., Levelt,C., Klooster,J., Geiger,S., Seeliger,M., Rashbass,P., Le Bivic,A., and Wijnholds,J. (2004). Crumbs homologue 1 is required for maintenance of photoreceptor cell polarization and adhesion during light exposure. J. Cell Sci. 117, 4169-4177.
35. Borst,P., Balzarini,J., Ono,N., Reid,G., de Vries,H., Wielinga,P., Wijnholds,J., and Zelcer,N. (2004). The potential impact of drug transporters on nucleoside-analog-based antiviral chemotherapy. Antiviral Res. 62, 1-7.
34. Hu,X., Plomp,A., Wijnholds,J., Ten Brink,J., van Soest,S., van den Born,L.I., Leys,A., Peek,R., de Jong,P.T., and Bergen,A.A. (2003a). ABCC6/MRP6 mutations: further insight into the molecular pathology of pseudoxanthoma elasticum. Eur. J. Hum. Genet. 11, 215-224.
33. Hu,X., Plomp,A.S., van Soest,S., Wijnholds,J., de Jong,P.T., and Bergen,A.A. (2003b). Pseudoxanthoma elasticum: a clinical, histopathological, and molecular update. Surv. Ophthalmol. 48, 424-438.
32. Reid,G., Wielinga,P., Zelcer,N., de Haas,M., Van Deemter,L., Wijnholds,J., Balzarini,J., and Borst,P. (2003a). Characterization of the transport of nucleoside analog drugs by the human multidrug resistance proteins MRP4 and MRP5. Mol. Pharmacol. 63, 1094-1103.
31. Reid,G., Wielinga,P., Zelcer,N., van,d.H., I, Kuil,A., de Haas,M., Wijnholds,J., and Borst,P. (2003b). The human multidrug resistance protein MRP4 functions as a prostaglandin efflux transporter and is inhibited by nonsteroidal antiinflammatory drugs. Proc. Natl. Acad. Sci. U.S.A. 100, 9244-9249.
30. Wielinga,P.R., van,d.H., I, Reid,G., Beijnen,J.H., Wijnholds,J., and Borst,P. (2003). Characterization of the MRP4- and MRP5-mediated transport of cyclic nucleotides from intact cells. J. Biol. Chem. 278, 17664-17671.
29. Wielinga,P.R., Reid,G., Challa,E.E., van,d.H., I, Van Deemter,L., de Haas,M., Mol,C., Kuil,A.J., Groeneveld,E., Schuetz,J.D., Brouwer,C., De Abreu,R.A., Wijnholds,J., Beijnen,J.H., and Borst,P. (2002). Thiopurine metabolism and identification of the thiopurine metabolites transported by MRP4 and MRP5 overexpressed in human embryonic kidney cells. Mol. Pharmacol. 62, 1321-1331.
28. Wijnholds,J. (2002). Drug resistance caused by multidrug resistance-associated proteins. Novartis. Found. Symp. 243, 69-79.
27. den Hollander,A.I., Ghiani,M., de Kok,Y.J., Wijnholds,J., Ballabio,A., Cremers,F.P., and Broccoli,V. (2002). Isolation of Crb1, a mouse homologue of Drosophila crumbs, and analysis of its expression pattern in eye and brain. Mech. Dev. 110, 203-207.
26. Scheffer,G.L., Hu,X., Pijnenborg,A.C., Wijnholds,J., Bergen,A.A., and Scheper,R.J. (2002). MRP6 (ABCC6) detection in normal human tissues and tumors. Lab Invest 82, 515-518.
25. ten Hove,T., Drillenburg,P., Wijnholds,J., Te Velde,A.A., and van Deventer,S.J. (2002). Differential susceptibility of multidrug resistance protein-1 deficient mice to DSS and TNBS-induced colitis. Dig. Dis. Sci. 47, 2056-2063.
24. Schultz,M.J., Wijnholds,J., Peppelenbosch,M.P., Vervoordeldonk,M.J., Speelman,P., van Deventer,S.J., Borst,P., and van der Poll,P.T. (2001). Mice lacking the multidrug resistance protein 1 are resistant to Streptococcus pneumoniae-induced pneumonia. J. Immunol. 166, 4059-4064.
23. Scheffer,G.L., Kool,M., Heijn,M., de Haas,M., Pijnenborg,A.C., Wijnholds,J., van Helvoort,A., de Jong,M.C., Hooijberg,J.H., Mol,C.A., van der,L.M., de Vree,J.M., van,d., V, Elferink,R.P., Borst,P., and Scheper,R.J. (2000). Specific detection of multidrug resistance proteins MRP1, MRP2, MRP3, MRP5, and MDR3 P-glycoprotein with a panel of monoclonal antibodies. Cancer Res. 60, 5269-5277.
22. Allen,J.D., Brinkhuis,R.F., Van Deemter,L., Wijnholds,J., and Schinkel,A.H. (2000). Extensive contribution of the multidrug transporters P-glycoprotein and Mrp1 to basal drug resistance. Cancer Res. 60, 5761-5766.
21. Wijnholds,J., de Lange,E.C., Scheffer,G.L., van den Berg,D.J., Mol,C.A., van,d., V, Schinkel,A.H., Scheper,R.J., Breimer,D.D., and Borst,P. (2000a). Multidrug resistance protein 1 protects the choroid plexus epithelium and contributes to the blood-cerebrospinal fluid barrier. J. Clin. Invest. 105, 279-285.
20. Wijnholds,J., Mol,C.A., Van Deemter,L., de Haas,M., Scheffer,G.L., Baas,F., Beijnen,J.H., Scheper,R.J., Hatse,S., De Clercq,E., Balzarini,J., and Borst,P. (2000b). Multidrug-resistance protein 5 is a multispecific organic anion transporter able to transport nucleotide analogs. Proc. Natl. Acad. Sci. U.S.A. 97, 7476-7481.
19. Borst,P., Evers,R., Kool,M., and Wijnholds,J. (2000). A family of drug transporters: the multidrug resistance-associated proteins. J. Natl. Cancer Inst. 92, 1295-1302.
18. Borst,P., Evers,R., Kool,M., and Wijnholds,J. (1999). The multidrug resistance protein family. Biochim. Biophys. Acta 1461, 347-357.
17. van Helvoort,A., de Brouwer,A., Ottenhoff,R., Brouwers,J.F., Wijnholds,J., Beijnen,J.H., Rijneveld,A., van der,P.T., van der Valk,M.A., Majoor,D., Voorhout,W., Wirtz,K.W., Elferink,R.P., and Borst,P. (1999). Mice without phosphatidylcholine transfer protein have no defects in the secretion of phosphatidylcholine into bile or into lung airspaces. Proc. Natl. Acad. Sci. U.S.A. 96, 11501-11506.
16. Allen,J.D., Brinkhuis,R.F., Wijnholds,J., and Schinkel,A.H. (1999). The mouse Bcrp1/Mxr/Abcp gene: amplification and overexpression in cell lines selected for resistance to topotecan, mitoxantrone, or doxorubicin. Cancer Res. 59, 4237-4241.
15. Wijnholds,J., Scheffer,G.L., van,d., V, van,d., V, Beijnen,J.H., Scheper,R.J., and Borst,P. (1998). Multidrug resistance protein 1 protects the oropharyngeal mucosal layer and the testicular tubules against drug-induced damage. J. Exp. Med. 188, 797-808.
14. Wijnholds,J., Evers,R., van Leusden,M.R., Mol,C.A., Zaman,G.J., Mayer,U., Beijnen,J.H., van,d., V, Krimpenfort,P., and Borst,P. (1997). Increased sensitivity to anticancer drugs and decreased inflammatory response in mice lacking the multidrug resistance-associated protein. Nat. Med. 3, 1275-1279.
13. Evers,R., Cnubben,N.H., Wijnholds,J., Van Deemter,L., van Bladeren,P.J., and Borst,P. (1997). Transport of glutathione prostaglandin A conjugates by the multidrug resistance protein 1. FEBS Lett. 419, 112-116.
12. Smidt,M.P., Russchen,B., Snippe,L., Wijnholds,J., and Ab,G. (1995). Cloning and characterisation of a nuclear, site specific ssDNA binding protein. Nucleic Acids Res. 23, 2389-2395.
11. Wijnholds,J., Chowdhury,K., Wehr,R., and Gruss,P. (1995). Segment-specific expression of the neuronatin gene during early hindbrain development. Dev. Biol. 171, 73-84.
10. Smidt,M.P., Wijnholds,J., Snippe,L., van Keulen,G., and Ab,G. (1994). Binding of a bZip protein to the estrogen-inducible apoVLDL II promoter. Biochim. Biophys. Acta 1219, 115-120.
9. Chalepakis,G., Wijnholds,J., Giese,P., Schachner,M., and Gruss,P. (1994a). Characterization of Pax-6 and Hoxa-1 binding to the promoter region of the neural cell adhesion molecule L1. DNA Cell Biol. 13, 891-900.
8. Chalepakis,G., Wijnholds,J., and Gruss,P. (1994b). Pax-3-DNA interaction: flexibility in the DNA binding and induction of DNA conformational changes by paired domains. Nucleic Acids Res. 22, 3131-3137.
7. Wijnholds,J., Philipsen,S., Pruzina,S., Fraser,P., Grosveld,F., and Ab,G. (1993). Estrogen-inducible and liver-specific expression of the chicken Very Low Density Apolipoprotein II gene locus in transgenic mice. Nucleic Acids Res. 21, 1629-1635.
6. Chalepakis,G., Stoykova,A., Wijnholds,J., Tremblay,P., and Gruss,P. (1993). Pax: gene regulators in the developing nervous system. J. Neurobiol. 24, 1367-1384.
5. Calkhoven,C.F., Ab,G., and Wijnholds,J. (1992). c/CEPB, a chicken transcription factor of the leucine-zipper C/EBP family. Nucleic Acids Res. 20, 4093.
4. Wijnholds,J., Muller,E., and Ab,G. (1991). Oestrogen facilitates the binding of ubiquitous and liver-enriched nuclear proteins to the apoVLDL II promoter in vivo. Nucleic Acids Res. 19, 33-41.
3. Beekman,J.M., Wijnholds,J., Schippers,I.J., Pot,W., Gruber,M., and Ab,G. (1991). Regulatory elements and DNA-binding proteins mediating transcription from the chicken very-low-density apolipoprotein II gene. Nucleic Acids Res. 19, 5371-5377.
2. Wijnholds,J., Philipsen,J.N., and Ab,G. (1988). Tissue-specific and steroid-dependent interaction of transcription factors with the oestrogen-inducible apoVLDL II promoter in vivo. EMBO J. 7, 2757-2763.
1. Smit,M.J., Wijnholds,J., Duursma,A.M., Bouma,J.M., and Gruber,M. (1986). Plasma clearance of mitochondrial aspartate aminotransferase in the rat: competition with mitochondrial malate dehydrogenase. Biomed. Biochim. Acta 45, 1557-1561.