Jan Wijnholds track record

Total number of manuscripts is 69, citations >5800; Hirsch factor 37

9 key papers published within the last 6 years (S: first or last author):

Pellissier LP, Lundvig DMS, Tanimoto N, Klooster J, Vos RM, Richard F, Sothilingam V, Garcia Garrido M, Le Bivic A, Seeliger MW, and Wijnholds J (2014) CRB2 acts as a modifying factor of CRB1-related retinal dystrophies in mice. Hum Mol Genet In press [5y-IF 7.5] S

Alves CH, Pellissier LP, Vos RM, Garrido MG, Sothilingam V, Seide C, Beck SC, Klooster J, Furukawa T, Flannery JG, Verhaagen J, Seeliger MW, Wijnholds J (2014) Targeted ablation of Crb2 in Photoreceptor Cells induces Retinitis Pigmentosa. Hum Mol Genet In press [5y-IF 7.5] S

Alves CH, Pellissier LP, Wijnholds J (2014) The CRB1 and adherens junction complex proteins in retinal development and maintenance. Prog Retin Eye Res 40:35-42 [5y-IF 10.2] S

Pellissier LP, Alves CH, Quinn PM, Vos RM, Tanimoto N, Lundvig DMS, Dudok JJ, Hooibrink B, Richard F, Beck SC, Huber G, Sothilingam V, Garcia-Garrido M, Le Bivic A, Seeliger MW, and Wijnholds J (2013) Targeted Ablation of Crb1 and Crb2 in Retinal Progenitor Cells Mimics Leber Congenital Amaurosis. PLoS Genet 9:e1003976 [5y-IF 9.4] S

Alves CH, Sanz AS, Park B, Pellissier LP, Tanimoto N, Beck SC, Huber G, Murtaza M, Richard F, Sridevi Gurubaran I, Garcia-Garrido M, Levelt CN, Rashbass P, Le Bivic A, Seeliger MW and Wijnholds J (2013) Loss of CRB2 in the mouse retina mimics human Retinitis Pigmentosa due to mutations in the CRB1 gene. Hum Mol Genet 22:35-50 [5y-IF 7.5] S

Dudok JJ, Sanz AS, Lundvig DMS, and Wijnholds J (2013) MPP3 is required for maintenance of the apical junctional complex, neuronal migration and stratification in the developing cortex. J. Neurosci 33:8518-27 [5y-IF 7.9] S

Park B, Alves CH, Lundvig DM, Tanimoto N, Beck SC, Huber G, Richard F, Klooster J, Andlauer TF, Swindell EC, Jamrich M, Le Bivic A, Seeliger MW and Wijnholds J (2011) PALS1 is essential for retinal pigment epithelium structure and neural retina stratification. J Neurosci 31:17230-17241  [5y-IF 7.9] S

Kim S, Lehtinen MK, Sessa A, Zappaterra MW, Cho S-H, Gonzalez D, Boggan B, Austin CA, Wijnholds J, Gambello MJ, Malicki J, LaMantia AS, Broccoli V and Walsh CA (2010) The apical complex couples cell fate and cell survival to cerebral cortical development. Neuron 66, 69-84 [5y-IF 16.4]

Stöhr H, Heisig JB, Benz PM, Schöberl S, Milenkovic VM, Strauss O, Aartsen WM, Wijnholds J, Weber BH, Schulz HL (2009) TMEM16B, a novel protein with calcium-dependent chloride channel activity, associates with a presynaptic protein complex in photoreceptor terminals. J Neurosci 29:6809-18 [5y-IF 7.9]

Selected 34 Key Papers in 25 years (S: first or last author):

Pellissier LP, Lundvig DMS, Tanimoto N, Klooster J, Vos RM, Richard F, Sothilingam V, Garcia Garrido M, Le Bivic A, Seeliger MW, and Wijnholds J (2014) CRB2 acts as a modifying factor of CRB1-related retinal dystrophies in mice. Hum Mol Genet In press [5y-IF 7.5] S

Alves CH, Pellissier LP, Vos RM, Garrido MG, Sothilingam V, Seide C, Beck SC, Klooster J, Furukawa T, Flannery JG, Verhaagen J, Seeliger MW, Wijnholds J (2014) Targeted ablation of Crb2 in Photoreceptor Cells induces Retinitis Pigmentosa. Hum Mol Genet In Press [5y-IF 7.5] S

Alves CH, Pellissier LP, Wijnholds J (2014) The CRB1 and adherens junction complex proteins in retinal development and maintenance. Prog Retin Eye Res 40:35-42 [5y-IF 10.2] S

Pellissier LP, Alves CH, Quinn PM, Vos RM, Tanimoto N, Lundvig DMS, Dudok JJ, Hooibrink B, Richard F, Beck SC, Huber G, Sothilingam V, Garcia-Garrido M, Le Bivic A, Seeliger MW, and Wijnholds J (2013) Targeted Ablation of Crb1 and Crb2 in Retinal Progenitor Cells Mimics Leber Congenital Amaurosis. PLoS Genet 9:e1003976 [5y-IF 9.4] S

Dudok JJ, Sanz AS, Lundvig DMS, and Wijnholds J (2013) MPP3 is required for maintenance of the apical junctional complex, neuronal migration and stratification in the developing cortex. J. Neurosci 33:8518-27 [5y-IF 7.9] S

Alves CH, Sanz AS, Park B, Pellissier LP, Tanimoto N, Beck SC, Huber G, Murtaza M, Richard F, Sridevi Gurubaran I, Garcia-Garrido M, Levelt CN, Rashbass P, Le Bivic A, Seeliger MW and Wijnholds J (2013) Loss of CRB2 in the mouse retina mimics human Retinitis Pigmentosa due to mutations in the CRB1 gene. Hum Mol Genet 22:35-50 [5y-IF 7.5] S

Park B, Alves CH, Lundvig DM, Tanimoto N, Beck SC, Huber G, Richard F, Klooster J, Andlauer TF, Swindell EC, Jamrich M, Le Bivic A, Seeliger MW and Wijnholds J (2011) PALS1 is essential for retinal pigment epithelium structure and neural retina stratification. J Neurosci 31:17230-17241  [5y-IF 7.9] S

Kim S, Lehtinen MK, Sessa A, Zappaterra MW, Cho S-H, Gonzalez D, Boggan B, Austin CA, Wijnholds J, Gambello MJ, Malicki J, LaMantia AS, Broccoli V and Walsh CA (2010) The apical complex couples cell fate and cell survival to cerebral cortical development. Neuron 66, 69-84 [5y-IF 16.4]

Stöhr H, Heisig JB, Milenkovic V, Strauss O, Benz1 PM, Aartsen WM, Wijnholds J, Weber BHF and Schulz HL (2009) TMEM16B, a novel protein with calcium-dependent chloride channel activity, associates with a presynaptic protein complex in photoreceptor terminals. J Neurosci 29:6809-18 [5y-IF 7.9]

Van de Pavert SA, Meuleman J, Malysheva A, Aartsen WM, Versteeg I, Tonagel T, Kamphuis W, McCabe CJ, Seeliger MW and Wijnholds J (2007) A single amino acid substitution (Cys249Trp) in the sixth epidermal growth factor (EGF) domain of Crb1 causes retinal degeneration and deregulates expression of Pituitary tumor transforming gene 1 (Pttg1). J Neurosci, 27:564-573  [5y-IF 7.9] S

van Rossum AG, Aartsen WM, Meuleman J, Klooster J, Malysheva A, Versteeg I, Arsanto J-P, Le Bivic A and Wijnholds J (2006) Pals1/Mpp5 is required for correct localization of Crb1 at the sub-apical region in polarized Müller glia cells. Hum Mol Genet, 15 :2659-72  [5y-IF 7.5] S

Richard M, Roepman R, Aartsen WM, van Rossum AG, den Hollander AI, Knust E, Wijnholds J and Cremers FP (2006) Towards understanding CRUMBS function in retinal dystrophies. Hum Mol Genet, 15: R235-R243 [5y-IF 7.5]

Aartsen WM, Kantardzhieva A, Klooster J, van Rossum AG van de Pavert SA, Versteeg I, Nunes Cardozo B, Tonagel F, Beck SC, Tanimoto N, Seeliger MW and Wijnholds J (2006) Mpp4 recruits Psd95 and Veli3 towards the photoreceptor synapse. Hum Mol Genet, 15:1291-302 [5y-IF 7.5] S

Zelcer N, van de Wetering K, de Waart R, Scheffer G, Marschall HU, Wielinga P, Kuil A, Kunne C, Smith A, van der Valk M, Wijnholds J, Oude Elferink R and Borst P (2006)  Mice lacking Mrp3 (Abcc3) have normal bile salt transport, but display altered hepatic transport of endogenous glucuronides. J Hepatology, 44:768-75  [5y-IF 9.0]

Michel D, Arsanto JP, Massey-Harroche D, Beclin C, Wijnholds J and Le Bivic A (2005) PATJ connects and stabilizes apical and lateral components of tight junctions in human intestinal cells. J Cell Sci 118:4049-57 [5y-IF 6.4]

Wielinga P, Hooijberg JH, Gunnarsdottir G, Kathmann I, Reid R, Zelcer N, van der Born K, de Haas M, van der Heijden I, Kaspers G, Wijnholds J, Jansen G, Peters G and Borst P (2005) The human multidrug resistance protein MRP5 transports folates and can mediate cellular resistance against antifolates. Cancer Research 65:4425-30 [5y-IF 8.6]

van de Pavert S, Kantardzhieva A, Malysheva A, Meuleman J, Versteeg I, Levelt C, Klooster J, Geiger S, Seeliger M, Rashbass P, Le Bivic A and Wijnholds J (2004) Crumbs homologue 1 is required for maintenance of photoreceptor cell polarization and adhesion during light exposure. J Cell Sci 117, 4169-4177 [5y-IF 6.4] S

Reid G, Wielinga P, Zelcer N, van dH I, Kuil A, de Haas M, Wijnholds J and Borst P (2003) The human multidrug resistance protein MRP4 functions as a prostaglandin efflux transporter and is inhibited by nonsteroidal antiinflammatory drugs. Proc Natl Acad Sci USA 100, 9244-9249 [5y-IF 10.6]

Scheffer GL, Kool M, Heijn M, de Haas M, Pijnenborg AC, Wijnholds J, van Helvoort A, de Jong MC, Hooijberg JH, Mol CA, van der LM, de Vree JM, van d V, Elferink RP, Borst P, and Scheper RJ (2000) Specific detection of multidrug resistance proteins MRP1, MRP2, MRP3, MRP5, and MDR3 P-glycoprotein with a panel of monoclonal antibodies. Cancer Res 60, 5269-5277 [5y-IF 8.6]

Allen JD, Brinkhuis RF, Van Deemter L, Wijnholds J and Schinkel AH (2000) Extensive contribution of the multidrug transporters P-glycoprotein and Mrp1 to basal drug resistance. Cancer Res 60, 5761-5766 [5y-IF 8.6]

Wijnholds J, de Lange EC, Scheffer GL, van den Berg DJ, Mol CA, van d V, Schinkel AH, Scheper RJ, Breimer DD and Borst P (2000a) Multidrug resistance protein 1 protects the choroid plexus epithelium and contributes to the blood-cerebrospinal fluid barrier. J Clin Invest 105, 279-285 [5y-IF 14.7] S

Wijnholds J, Mol CA, Van Deemter L, de Haas M, Scheffer GL, Baas F, Beijnen JH, Scheper RJ, Hatse S, De Clercq E, Balzarini J and Borst P (2000b) Multidrug-resistance protein 5 is a multispecific organic anion transporter able to transport nucleotide analogs. Proc Natl Acad Sci USA 97, 7476-7481 [5y-IF 10.6] S

Borst P, Evers R, Kool M and Wijnholds J (2000) A family of drug transporters: the multidrug resistance-associated proteins. J Natl Cancer Inst 92, 1295-1302 [5y-IF 14.8] S

van Helvoort A, de Brouwer A, Ottenhoff R, Brouwers JF, Wijnholds J, Beijnen JH, Rijneveld A, van der PT, van der Valk MA, Majoor D, Voorhout W, Wirtz KW, Elferink RP and Borst P (1999) Mice without phosphatidylcholine transfer protein have no defects in the secretion of phosphatidylcholine into bile or into lung airspaces. Proc Natl Acad Sci USA 96, 11501-11506 [5y-IF 10.6]

Allen JD, Brinkhuis RF, Wijnholds J and Schinkel AH (1999) The mouse Bcrp1/Mxr/Abcp gene: amplification and overexpression in cell lines selected for resistance to topotecan, mitoxantrone, or doxorubicin. Cancer Res 59, 4237-4241 [5y-IF 8.6]

Wijnholds J, Scheffer GL, van der Valk M, van der Valk P, Beijnen JH, Scheper RJ and Borst,P (1998) Multidrug resistance protein 1 protects the oropharyngeal mucosal layer and the testicular tubules against drug-induced damage. J Exp Med 188, 797-808 [5y-IF 14.1] S

Wijnholds J, Evers R, van Leusden MR, Mol CA, Zaman GJ, Mayer U, Beijnen JH, van d V, Krimpenfort P and Borst P (1997) Increased sensitivity to anticancer drugs and decreased inflammatory response in mice lacking the multidrug resistance-associated protein. Nat Med 3, 1275-1279 [5y-IF 26.4] S

Smidt MP, Russchen B, Snippe L, Wijnholds J, and AB G (1995) Cloning and characterisation of a nuclear, site specific ssDNA binding protein. Nucleic Acids Res 23, 2389-2395 [5y-IF 8.1]

Chalepakis G, Wijnholds J and Gruss P (1994b) Pax-3-DNA interaction: flexibility in the DNA binding and induction of DNA conformational changes by paired domains. Nucleic Acids Res 22, 3131-3137 [5y-IF 8.1] S

Wijnholds J, Philipsen S, Pruzina S, Fraser P, Grosveld F and AB G (1993) Estrogen-inducible and liver-specific expression of the chicken Very Low Density Apolipoprotein II gene locus in transgenic mice. Nucleic Acids Res 21, 1629-1635 [5y-IF 8.1] S

Calkhoven CF, AB G and Wijnholds J (1992) c/CEPB, a chicken transcription factor of the leucine-zipper C/EBP family. Nucleic Acids Res 20, 4093 [5y-IF 8.1] S

Wijnholds J, Muller E and AB G (1991) Oestrogen facilitates the binding of ubiquitous and liver-enriched nuclear proteins to the apoVLDL II promoter in vivo. Nucleic Acids Res 19, 33-41 [5y-IF 8.1] S

Beekman JM, Wijnholds J, Schippers IJ, Pot W, Gruber M and AB G (1991) Regulatory elements and DNA-binding proteins mediating transcription from the chicken very-low-density apolipoprotein II gene. Nucleic Acids Res 19, 5371-5377 [5y-IF 8.1]

Wijnholds J, Philipsen JN and AB G (1988) Tissue-specific and steroid-dependent interaction of transcription factors with the oestrogen-inducible apoVLDL II promoter in vivo. EMBO J 7, 2757-2763[5y-IF 9.6] S

All papers:

69►  Pellissier LP, Lundvig DMS, Tanimoto N, Klooster J, Vos RM, Richard F, Sothilingam V, Garcia Garrido M, Le Bivic A, Seeliger MW, and Wijnholds J (2014) CRB2 acts as a modifying factor of CRB1-related retinal dystrophies in mice. Hum Mol Genet In press

68  Pellissier LP, Hoek RM, Vos RM, Aartsen WM, Klimczak RR, Hoyng SA, Flannery JG, Wijnholds J (2014) Specific tools for targeting and expression of Muller glia cells. Mol Ther Methods & Clinical Dev 1:14009

67  Alves CH, Pellissier LP, Wijnholds J (2014) The CRB1 and adherens junction complex proteins in retinal development and maintenance. Prog Retin Eye Res 40:35-42

66►  Alves CH, Pellissier LP, Vos RM, Garrido MG, Sothilingam V, Seide C, Beck SC, Klooster J, Furukawa T, Flannery JG, Verhaagen J, Seeliger MW, Wijnholds J (2014) Targeted ablation of Crb2 in Photoreceptor Cells induces Retinitis Pigmentosa. Hum Mol Genet In press

65►  Alves CH, Bossers K, Vos RM, Essing AHW, Swagemakers S, van der Spek PJ, Verhaagen J and Wijnholds J (2013) Microarray and morphological analysis of early postnatal CRB2 mutant retinas on a pure C57BL/6J genetic background. PloS ONE 8:e82532

64►  Pellissier LP, Alves CH, Quinn PM, Vos RM, Tanimoto N, Lundvig DMS, Dudok JJ, Hooibrink B, Richard F, Beck SC, Huber G, Sothilingam V, Garcia-Garrido M, Le Bivic A, Seeliger MW, and Wijnholds J (2013) Targeted Ablation of Crb1 and Crb2 in Retinal Progenitor Cells Mimics Leber Congenital Amaurosis. PLoS Genet 9:e1003976

63►  Dudok JJ, Sanz AS, Lundvig DMS, Sothilingam V, Garcia-Garrido M, Klooster J, Seeliger MW and Wijnholds J (2013) MPP3 regulates levels of PALS1 and adhesion between photoreceptors and Muller glia cells. Glia 61:1629-44

62►  Assémat E, Crost E, Ponserre M, Wijnholds J, Le Bivic A, Massey-Harroche D.  (2013) The Multi-Pdz Domain Protein-1 (Mupp-1) Expression Regulates Cellular Levels Of The Pals-1/Patj Polarity Complex. Exp. Cell Res 319:2514-2525.

61►  Dudok JJ, Sanz AS, Lundvig DMS, and Wijnholds J (2013) MPP3 is required for maintenance of the apical junctional complex, neuronal migration and stratification in the developing cortex. J. Neurosci 33:8518-27

60► Alves CH, Sanz AS, Park B, Pellissier LP, Tanimoto N, Beck SC, Huber G, Murtaza M, Richard F, Sridevi Gurubaran I, Garcia-Garrido M, Levelt CN, Rashbass P, Le Bivic A, Seeliger MW and Wijnholds J (2013) Loss of CRB2 in the mouse retina mimics human Retinitis Pigmentosa due to mutations in the CRB1 gene. Hum Mol Genet 22:35-50

59►  Park B, Alves CH, Lundvig DM, Tanimoto N, Beck SC, Huber G, Richard F, Klooster J, Andlauer TF, Swindell EC, Jamrich M, Le Bivic A, Seeliger MW and Wijnholds J (2011) PALS1 is essential for retinal pigment epithelium structure and neural retina stratification. J Neurosci 31:17230-17241 

58►  Aartsen WM, van Cleef KWR, Pellissier L, Hoek RM, Vos RM, Blits B, Ehlert EME, Balaggan KS, Ali RR, Verhaagen J and Wijnholds J (2010) GFAP-driven transgene expression in activated Müller glial cells following intravitreal injection of AAV2/6 vectors. PLoS One 5:e12387

57► Kim S, Lehtinen MK, Sessa A, Zappaterra MW, Cho S-H, Gonzalez D, Boggan B, Austin CA, Wijnholds J, Gambello MJ, Malicki J, LaMantia AS, Broccoli V and Walsh CA (2010) The apical complex couples cell fate and cell survival to cerebral cortical development. Neuron 66, 69-84 
56► Jaissle GB, May CA, van de Pavert SA, Wenzel A, Claes-May E, Giessle A, Szurman P, Wolfrum U, Wijnholds J, Fisher MD, Humphries P and Seeliger MW (2010) Bone spicule pigment formation in retinitis pigmentosa: insights from a mouse model. Graefes Arch Clin Exp Ophthalmol 248:1063-70 
55► Fischer MD, Huber G, Beck SC, Tanimoto N, Muehlfriedel R, Fahl E, Grimm C, Wenzel A, Remé CE, van de Pavert SA, Wijnholds J, Pacal M, Bremner R and Seeliger MW (2009) Noninvasive, in vivo assessment of mouse retinal structure using optical coherence tomography. PLoS One 4:e7507 

54► Stöhr H, Heisig JB, Milenkovic V, Strauss O, Benz1 PM, Aartsen WM, Wijnholds J, Weber BHF and Schulz HL (2009) TMEM16B, a novel protein with calcium-dependent chloride channel activity, associates with a presynaptic protein complex in photoreceptor terminals. J Neurosci 29:6809-18

53► Aartsen WM, Arsanto J-P, Chauvin J-P, Vos RM, Versteeg I, Nunes Cardozo B, Le Bivic A, and Wijnholds J (2009) PSD95β regulates plasma membrane Ca(2+) pump localization at the photoreceptor synapse. Mol Cell Neurosci 41:156-65

52► de Wolf C, Jansen R, Yamaguchi H, de Haas M, van de Wetering K, Schinkel A, Wijnholds J, Beijen J and Borst P (2008) Contribution of the drug transporter ABCG2 (Breast Cancer Resistance Protein) to resistance against anti-cancer nucleosides. Mol. Cancer Therapeutics, 7:3092-102

51► Van de Pavert SA, Sanz Sanz A, Aartsen WM, Vos RM, Versteeg I, Beck SC, Klooster J, Seeliger MW and Wijnholds J (2007) Crb1 is a determinant of retinal apical Mueller glia cell features. Glia 55(14):1486-97

50► Van de Pavert SA, Meuleman J, Malysheva A, Aartsen WM, Versteeg I, Tonagel T, Kamphuis W, McCabe CJ, Seeliger MW and Wijnholds J (2007) A single amino acid substitution (Cys249Trp) in the sixth epidermal growth factor (EGF) domain of Crb1 causes retinal degeneration and deregulates expression of Pituitary tumor transforming gene 1 (Pttg1). J Neurosci, 27:564-573

 49► de Wolf CJF, Yamaguchi H, van der Heijden I, Wielinga PR, Hundscheid SL, Ono N, Scheffer GL, de Haas M, Schuetz JD, Wijnholds J and Borst P (2007) cGMP transport by vesicles from human and mouse erythrocytes. FEBS J, 274:439-450 

48 Gavarini S, Becamel C, Altier C, Lory P, Poncet J, Wijnholds J, Bockaert J and Marin P (2006) Opposite effects of PSD-95 and MPP3 PDZ proteins on serotonin 5-HT2C receptor desensitization and membrane stability. Mol Biol Cell, 17: 4619-4631

 47 van Rossum AG, Aartsen WM, Meuleman J, Klooster J, Malysheva A, Versteeg I, Arsanto J-P, Le Bivic A and Wijnholds J (2006) Pals1/Mpp5 is required for correct localization of Crb1 at the sub-apical region in polarized Müller glia cells. Hum Mol Genet, 15 :2659-72 

46 Richard M, Roepman R, Aartsen WM, van Rossum AG, den Hollander AI, Knust E, Wijnholds J and Cremers FP (2006) Towards understanding CRUMBS function in retinal dystrophies. Hum Mol Genet, 15: R235-R243

45 Aartsen WM, Kantardzhieva A, Klooster J, van Rossum AG van de Pavert SA, Versteeg I, Nunes Cardozo B, Tonagel F, Beck SC, Tanimoto N, Seeliger MW and Wijnholds J (2006) Mpp4 recruits Psd95 and Veli3 towards the photoreceptor synapse. Hum Mol Genet, 15:1291-302

44► Kantardzhieva A, Alexeeva S, Versteeg I, and Wijnholds J (2006) MPP3 is recruited to the MPP5 protein scaffold at the retinal outer limiting membrane. FEBS J 273:1152-1165

43 Minich T, Riemer J, Schultz JB, Wielinga P, Wijnholds J and Dringen R (2006) The multidrug resistance protein 1 (Mrp1), but not Mrp5, mediates export of glutathione and glutathione disulfide from brain astrocytes. J Neurochem, 97:373-384

 42 Zelcer N, van de Wetering K, de Waart R, Scheffer G, Marschall HU, Wielinga P, Kuil A, Kunne C, Smith A, van der Valk M, Wijnholds J, Oude Elferink R and Borst P (2006)  Mice lacking Mrp3 (Abcc3) have normal bile salt transport, but display altered hepatic transport of endogenous glucuronides. J Hepatology, 44:768-75 

41 Seeliger MW, Beck S, Pereyra-Muñoz N, Dangel S, Tsai J-Y, Luhmann U, van de Pavert S, Wijnholds J, Samardzija M, Wenzel A, Zrenner E, Fahl E, Tanimoto N, Acar N and Tonagel F (2005) In vivo confocal imaging of the retina in animal models using scanning laser ophthalmoscopy Vision Res 45:3512-9

40 Michel D, Arsanto JP, Massey-Harroche D, Beclin C, Wijnholds J and Le Bivic A (2005) PATJ connects and stabilizes apical and lateral components of tight junctions in human intestinal cells. J Cell Sci 118:4049-57

39 Kantardzhieva A, Gosens I, Alexeeva S, Punte IM, Versteeg I, Krieger E, Neefjes-Mol CA, den Hollander AI, Letteboer SJF,  Klooster J, Cremers FPM, Roepman R and Wijnholds J (2005) MPP5 recruits MPP4 to the CRB1 complex in photoreceptors. Invest Ophthalmol Vis Sci 46:2192-201 

38 Wielinga P, Hooijberg JH, Gunnarsdottir G, Kathmann I, Reid R, Zelcer N, van der Born K, de Haas M, van der Heijden I, Kaspers G, Wijnholds J, Jansen G, Peters G and Borst P (2005) The human multidrug resistance protein MRP5 transports folates and can mediate cellular resistance against antifolates. Cancer Research 65:4425-30

37 Meuleman J, van de Pavert S and Wijnholds J (2004) Crumbs homologue 1 in polarity and blindness. Biochem Soc Trans, 32, 828-830

36► van de Pavert S, Kantardzhieva A, Malysheva A, Meuleman J, Versteeg I, Levelt C, Klooster J, Geiger S, Seeliger M, Rashbass P, Le Bivic A and Wijnholds J (2004) Crumbs homologue 1 is required for maintenance of photoreceptor cell polarization and adhesion during light exposure. J Cell Sci 117, 4169-4177

35 Borst P, Balzarini J, Ono N, Reid G, de Vries H, Wielinga P, Wijnholds J and Zelcer N (2004) The potential impact of drug transporters on nucleoside-analog-based antiviral chemotherapy. Antiviral Res 62, 1-7

34 Hu X, Plomp A, Wijnholds J, Ten Brink J, van Soest S, van den Born LI, Leys A, Peek R, de Jong PT and Bergen AA (2003a) ABCC6/MRP6 mutations: further insight into the molecular pathology of pseudoxanthoma elasticum. Eur J Hum Genet 11, 215-224

33 Hu X, Plomp AS, van Soest S, Wijnholds J, de Jong PT and Bergen AA (2003b) Pseudoxanthoma elasticum: a clinical, histopathological, and molecular update Surv Ophthalmol 48, 424-438

32 Reid G, Wielinga P, Zelcer N, de Haas M, Van Deemter L, Wijnholds J, Balzarini J and Borst P (2003a) Characterization of the transport of nucleoside analog drugs by the human multidrug resistance proteins MRP4 and MRP5. Mol Pharmacol 63, 1094-1103

31 Reid G, Wielinga P, Zelcer N, van dH I, Kuil A, de Haas M, Wijnholds J and Borst P (2003b) The human multidrug resistance protein MRP4 functions as a prostaglandin efflux transporter and is inhibited by nonsteroidal antiinflammatory drugs. Proc Natl Acad Sci USA 100, 9244-9249

30 Wielinga PR, van dH I, Reid G, Beijnen JH, Wijnholds J and Borst P (2003) Characterization of the MRP4- and MRP5-mediated transport of cyclic nucleotides from intact cells. J Biol Chem 278, 17664-17671

29 Wielinga PR, Reid G, Challa EE, van dH I, Van Deemter L, de Haas M, Mol C, Kuil AJ, Groeneveld E, Schuetz JD, Brouwer C, De Abreu RA, Wijnholds J, Beijnen JH and BorstP (2002) Thiopurine metabolism and identification of the thiopurine metabolites transported by MRP4 and MRP5 overexpressed in human embryonic kidney cells. Mol Pharmacol 62, 1321-1331

28 Wijnholds J (2002) Drug resistance caused by multidrug resistance-associated proteins. Novartis Found Symp 243, 69-79

27 den Hollander AI, Ghiani M, de Kok YJ, Wijnholds J, Ballabio A, Cremers FP and Broccoli V (2002) Isolation of Crb1, a mouse homologue of Drosophila crumbs, and analysis of its expression pattern in eye and brain. Mech Dev 110, 203-207

26 Scheffer GL, Hu X, Pijnenborg AC, Wijnholds J, Bergen AA and Scheper RJ (2002) MRP6 (ABCC6) detection in normal human tissues and tumors. Lab Invest 82, 515-518

25 ten Hove T, Drillenburg P, Wijnholds J, Te Velde AA and van Deventer SJ (2002) Differential susceptibility of multidrug resistance protein-1 deficient mice to DSS and TNBS-induced colitis. Dig Dis Sci 47, 2056-2063

24 Schultz MJ, Wijnholds J, Peppelenbosch MP, Vervoordeldonk MJ, Speelman P, van Deventer SJ, Borst P and van der Poll PT (2001) Mice lacking the multidrug resistance protein 1 are resistant to Streptococcus pneumoniae-induced pneumonia. J Immunol 166, 4059-4064

23 Scheffer GL, Kool M, Heijn M, de Haas M, Pijnenborg AC, Wijnholds J, van Helvoort A, de Jong MC, Hooijberg JH, Mol CA, van der LM, de Vree JM, van d V, Elferink RP, Borst P, and Scheper RJ (2000) Specific detection of multidrug resistance proteins MRP1, MRP2, MRP3, MRP5, and MDR3 P-glycoprotein with a panel of monoclonal antibodies. Cancer Res 60, 5269-5277

22 Allen JD, Brinkhuis RF, Van Deemter L, Wijnholds J and Schinkel AH (2000) Extensive contribution of the multidrug transporters P-glycoprotein and Mrp1 to basal drug resistance. Cancer Res 60, 5761-5766

21 Wijnholds J, de Lange EC, Scheffer GL, van den Berg DJ, Mol CA, van d V, Schinkel AH, Scheper RJ, Breimer DD and Borst P (2000a) Multidrug resistance protein 1 protects the choroid plexus epithelium and contributes to the blood-cerebrospinal fluid barrier. J Clin Invest 105, 279-285

20 Wijnholds J, Mol CA, Van Deemter L, de Haas M, Scheffer GL, Baas F, Beijnen JH, Scheper RJ, Hatse S, De Clercq E, Balzarini J and Borst P (2000b) Multidrug-resistance protein 5 is a multispecific organic anion transporter able to transport nucleotide analogs Proc Natl Acad Sci USA 97, 7476-7481

19 Borst P, Evers R, Kool M and Wijnholds J (2000) A family of drug transporters: the multidrug resistance-associated proteins J Natl Cancer Inst 92, 1295-1302

18 Borst P, Evers R, Kool M and Wijnholds J (1999) The multidrug resistance protein family Biochim Biophys Acta 1461, 347-357

17 van Helvoort A, de Brouwer A, Ottenhoff R, Brouwers JF, Wijnholds J, Beijnen JH, Rijneveld A, van der PT, van der Valk MA, Majoor D, Voorhout W, Wirtz KW, Elferink RP and Borst P (1999) Mice without phosphatidylcholine transfer protein have no defects in the secretion of phosphatidylcholine into bile or into lung airspaces Proc Natl Acad Sci USA 96, 11501-11506

16 Allen JD, Brinkhuis RF, Wijnholds J and Schinkel AH (1999) The mouse Bcrp1/Mxr/Abcp gene: amplification and overexpression in cell lines selected for resistance to topotecan, mitoxantrone, or doxorubicin. Cancer Res 59, 4237-4241

15 Wijnholds J, Scheffer GL, van d V, van d  V, Beijnen JH, Scheper RJ and Borst,P (1998) Multidrug resistance protein 1 protects the oropharyngeal mucosal layer and the testicular tubules against drug-induced damage. J Exp Med 188, 797-808

14 Wijnholds J, Evers R, van Leusden MR, Mol CA, Zaman GJ, Mayer U, Beijnen JH, van d V, Krimpenfort P and Borst P (1997) Increased sensitivity to anticancer drugs and decreased inflammatory response in mice lacking the multidrug resistance-associated protein. Nat Med 3, 1275-1279

13 Evers R, Cnubben NH, Wijnholds J, Van Deemter L, van Bladeren PJ and Borst P (1997) Transport of glutathione prostaglandin A conjugates by the multidrug resistance protein 1. FEBS Lett 419, 112-116

12 Smidt MP, Russchen B, Snippe L, Wijnholds J, and AB G (1995) Cloning and characterisation of a nuclear, site specific ssDNA binding protein. Nucleic Acids Res 23, 2389-2395

11 Wijnholds J, Chowdhury K, Wehr R and Gruss P (1995) Segment-specific expression of the neuronatin gene during early hindbrain development. Dev Biol 171, 73-84

10 Smidt MP, Wijnholds J, Snippe L, van Keulen G and AB G (1994) Binding of a bZip protein to the estrogen-inducible apoVLDL II promoter. Biochim Biophys Acta 1219, 115-120

9   Chalepakis G, Wijnholds J, Giese P, Schachner M  and Gruss P (1994a) Characterization of Pax-6 and Hoxa-1 binding to the promoter region of the neural cell adhesion molecule L1. DNA Cell Biol 13, 891-900

8   Chalepakis G, Wijnholds J and Gruss P (1994b) Pax-3-DNA interaction: flexibility in the DNA binding and induction of DNA conformational changes by paired domains Nucleic Acids Res 22, 3131-3137

7   Wijnholds J, Philipsen S, Pruzina S, Fraser P, Grosveld F and AB G (1993) Estrogen-inducible and liver-specific expression of the chicken Very Low Density Apolipoprotein II gene locus in transgenic mice. Nucleic Acids Res 21, 1629-1635

6   Chalepakis G, Stoykova A, Wijnholds J, Tremblay P and Gruss P (1993) Pax: gene regulators in the developing nervous system. J Neurobiol 24, 1367-1384

5   Calkhoven CF, AB G and Wijnholds J (1992) c/CEPB, a chicken transcription factor of the leucine-zipper C/EBP family. Nucleic Acids Res 20, 4093

4   Wijnholds J, Muller E and AB G (1991) Oestrogen facilitates the binding of ubiquitous and liver-enriched nuclear proteins to the apoVLDL II promoter in vivo. Nucleic Acids Res 19, 33-41

3   Beekman JM, Wijnholds J, Schippers IJ, Pot W, Gruber M and AB G (1991) Regulatory elements and DNA-binding proteins mediating transcription from the chicken very-low-density apolipoprotein II gene. Nucleic Acids Res 19, 5371-5377

2   Wijnholds J, Philipsen JN and AB G (1988) Tissue-specific and steroid-dependent interaction of transcription factors with the oestrogen-inducible apoVLDL II promoter in vivo. EMBO J 7, 2757-2763

1   Smit MJ, Wijnholds J, Duursma AM, Bouma JM and Gruber M (1986) Plasma clearance of mitochondrial aspartate aminotransferase in the rat: competition with mitochondrial malate dehydrogenase. Biomed Biochim Acta 45, 1557-1561

Thesis Albena Kantardzhieva