Neuromedical Genetics - Jan Wijnholds

Research in our team is focused on mechanisms of retinal degeneration and gene therapy. We presently study the role of Crumbs, MAGUK and interacting proteins in photoreceptors, Müller glia cells and the brain. Our goal is to understand the processes that underlie deregulated photoreceptor cell polarization and adhesion in retinal degeneration and stimulate to apply this knowledge in the development of therapeutic tools. 

Foundation Fighting Blindness funds CRB1 Gene Therapy project (2011)

Kim,S., Lehtinen,M.K., Sessa,A., Zappaterra,M.W., Cho,S.H., Gonzalez,D., Boggan,B., Austin,C.A., Wijnholds,J., Gambello,M.J., Malicki,J., LaMantia,A.S., Broccoli,V., and Walsh,C.A. The apical complex couples cell fate and cell survival to cerebral cortical development. Neuron 66 (2010) 69-84.

June 20-22, 2010; CRUMBS IN SIGHT consortium meeting Sausset les Pins.

In the media.