Publications

2012

Fitzsimons CP, Van Hooijdonk LWA, Schouten M, Zalachoras I, Brinks V, Zheng T, Schouten TG, Saaltink DJ, Dijkmans T, Steindler DA, Verhaagen J, Verbeek FJ, Lucassen PJ, De Kloet, ER, Meijer OC, Karst H, Joels M, Oitzl MS, Vreugdenhil E. Knockdown of the glucocorticoid receptor alters functional integration of newborn neurons in the adult hippocampus and impairs fear-motivated behavior. Mol Psychiatry. (in press)

 

Hutson TH, Verhaagen J, Yanez-Munoz RJ and Moon LD (2012) Corticospinal tract transduction: a comparison of seven AAV vector serotypes and a non-integrating lentiviral vector. Gene Ther 19 (2012): 49-60.

 

Roet KCD, Eggers R and Verhaagen J (2012) Non-invasive bioluminescence imaging of olfactory ensheathing glia and schwann cells following transplantation in the lesioned rat spinal cord. Cell Transplantation, Epub March 2012

 

Shakhbazau A, Kawasoe J, Hoyng SA, Kumar R, Van Minnen J, Verhaagen J and Midha R (2012) Early regenerative effects of NGF-transduced Schwann cells in peripheral nerve repair. Molecular and Cellular Neuroscience 50:103-112.

 

Sharma A, Verhaagen J, Harvey AR (2012) Receptor complexes for each of the class 3 semaphprins. Front Cell Neurosci 6:28

 

Verhaagen J, Van Kesteren RE, Bossers K, MacGillavry HD, Mason MR, Smit AB (in press). Molec-ular target discovery for neural repair in the functional genomics era. Handb Clin Neurol 109.

 

Wijte D, McDonnell LA, Balog CIA, Bossers K, Deelder AM, Swaab DF, Verhaagen J and Mayboroda OA (2012) A novel peptidomics approach to detect markers in cerebrospinal fluid of Alzheimer’s disease samples. Methods 56:500-507

 


2011

MacGillavry, H.D., Cornelis, J., van der Kallen, L.R., Sassen, M.M., Verhaagen, J., Smit, A.B., van Kestern, R.E. (2011) Genome-wide gene expression and promotor binding analysis identifies NFIL3 as a repressor of C/EBP target genes in neuronal outgrowth. Molec. Cell. Neurosci. 46: 460-468

Hellstrom, M., Muhling, J., Ehlert, E.M., Verhaagen, J., Pollett, M.A., Harvey, A.R. (2011) Negative impact of rAAV2-mediated expression of SOCS3 on the regeneration of adult retinal ganglion cell axons. Molec. Cell. Neurosci. 46: 507-515

Roet, K.C.D., Bossers, K., Franssen, E.H.P., Ruitenberg, M.J., Verhaagen, J. (2011) A meta-analysis of microarray-based expression studies of olfactory bulb-derived ensheathing cells. Exp. Neurol. 229: 10-45

Tewarie, R.D., Bossers, K., Ritfeld, G.J., Blits, B., Grotenhuis, J.A., Verhaagen, J., Oudega, M. (2011) Early passage bone marrow stromal cells express genes involved in nervous system development supporting their relevance for neural repair. Restor. Neurol. Neurosci. 29: 187-201

Geeven, G., MacGillavry, H.D., Eggers, R., Sassen, M.M., Verhaagen, J., Smit, A.B., de Gunst, M.C., Van Kesteren, R.E. (2011) LLMD3: a log-lineair modeling-based method to predict functional gene regulatory interactions from genome-wide expression data. Nucleic Acid Res. 39: 5313-5327

Mason, M.R., Tannemaat, M.R., Malessy, M.J., Verhaagen, J. (2011) Gene therapy for the peripheral nervous system: a strategy to repair the injure nerve? Curr. Gene Ther. 11: 75-89

Korecka, J.A., Schouten, M., Eggers, R., Ulusoy, A., Bossers, K., Verhaagen, J. (2011) Comparison of AAV serotypes for gene delivery to dopaminergic neurons in the substantia nigra. In Tech: Viral Gene Therapy, pp 205-224

Zhao R.R., Muir E.M., Alves J.N., Rickman H., Allan A.Y., Kwok J.C., Roet K.C., Verhaagen J, Schneider BL, Bensadoun J.C., Ahmed S.G., Yáñez-Muñoz R.J., Keynes R.J., Fawcett J.W., Rogers J.H. (2011) Lentiviral vectors express chondroitinase ABC in cortical projections and promote sprouting of ijured corticospinal axons. J. Neurosci. Methods 201: 228-238

Hoyng SA, Tannemaat MR, De Winter F, Verhaagen J, Malessy MJ. (2011) Nerve surgery and gene therapy: a neurobiological and clinical perspective. J. Hand Surgery, Epub Sept 13.

2010

Eggers, R.,Tannemaat, M.R., Ehlert, E.M., Verhaagen, J. (2010) A spatio-temporal analysis of motorneuron survival, axonal regeneration and neurotrophic factor expression after lumbar ventral root avulsion and implantation. Exp. Neurol. 223: 207-220

Blits, B., Derks, S., Twisk, J., Ehlert, E.M., Prins, J., Verhaagen, J. (2010) Adeno-associated viral vector (AAV)-mediated gene transfer in the red nucleus of the adult rat brain: comparative analysis of the transduction properties of seven AAV serotypes and lentiviral vectors. J. Neurosci. Meth. 185: 257-263

Zaldumbide A, Weening, S., Cramer S.J., Rabelink, M.J., Verhaagen, J., Hoeben R.C. (2010) A potentially immunologically inert derivative of the reverse tetracycline-controlled transactivator. Biotechnological letters 32: 749-754

Van Strien, M.E., Mercier, D., Drukarch, B., Breve, J.J., Poole, S., Binnekade, R., Bol, J.G., Blits, B., Verhaagen, J., Van Dam, A. (2010) Anti-inflammatory effect by lentiviral vector-mediated overexpression of IL-10 or IL-1 receptor antagonist in rat glial cells and macrophages. Gene Therapy: 17: 662-671

Ehlert, E.M., Eggers R., Niclou, S., Verhaagen, J. (2010) Cellular toxicity following adeno-associated viral vector-mediated delivery of RNAi to the nervous system. BMC-Neuroscience 11:20

Mason M.R., Ehlert, E.M., Eggers, R., Pool, C.W., Hermening, S., Huseinovic, A., Timmermans, E., Blits, B., Verhaagen, J. (2010)  Molec. Ther. 18: 715-724

Bossers, K., Ylstra, B., Brakenhoff, R.H., Smeets, S.J., Verhaagen, J., Van der Wiel, M.A. (2010) Intensity-based dual color gene expression data as an alternative to ratio-based analysis to enhance reproducibility. BMC Genomics 11: 112

Mamber, C., Verhaagen, J., Hol, E.M. (2010) In vivo targeting of subventricular zone astrocytes. Prog Neurobiol. 92: 19-32

Bossers, K., Wirz, K.T., Meerhoff, G.F., Essing, A.H., Van Dongen, J.W., Houba, P., Kruse C.G., Verhaagen, J., Swaab, D.F. (2010) Concerted changes in transcripts in the prefrontal cortex precede neuropathology in Alzheimer’s disease. Brain: 133: 3699-3723

Aartsen, W.M., Van Cleef, K.W., Pellissier, L.P., Hoek, R.M., Blits, B., Ehlert, E.M., Balaggan, K.S., Ali, R.R., Verhaagen, J., Wijnholds, J. (2010) GFAP-driven GFP expression in activated mouse Mueller glial cells aligning retinal blood vessels following intravitreal injection of AAV2/6 vectors. PlosOne 24: 5e12387


2009

Bossers, K., Meerhoff, G., Balesar, R., Van Dongen, J., Kruse, C., Swaab, D.F., Verhaagen J. (2009) Analysis of gene expression in Parkinson's disease: possible involvement of neurotrophic support and axon guidance in dopaminergic cell death. Brain Pathology 19: 91-107
 
Blits, B., Verhaagen, J. (2009) Gene therapy for neurological disease. Encyclopedia of Neuroscience (Springer) pp. 1682-1687
 
Verhaagen, J., Pasterkamp, R.J. (2009) Semaphorins. New Encyclopedia of Neuroscience (Elsevier) pp. 577 - 583.

Hellstrom, M., Ruitenberg, M.J., Pollett, M.A., Ehlert, E.M., Twisk, J., Verhaagen, J., Harvey A.R. (2009). Cellular tropism and transduction properties of seven adeno-associated viral vector serotypes in adult retina after intravitreal injection. Gene Therapy 16: 521-532
 
Vukovic, J., Ruitenberg, M.J., Roet, K., Franssen, E.H.P., Arulpragasam, A., Sasaki, T., Verhaagen, J., Harvey, A.R., Busfield, S.J., Plant, G.W. (2009) The glycoprotein fibulin-3 regulates morphology and motility of olfactory ensheathing cells in vitro. Glia 56: 1285-1298
 
Franssen E.H., Roet, K.C., De Bree, F.M., Verhaagen, J. (2009) Olfactory ensheathing glia and Schwann cells exhibit a distinct interaction behaviour with meningeal cells. J. Neurosci. Res. 87: 1556-1564
 
Tannemaat, M.R., Boer, G.J., Eggers, R., Malessy, M.J., Verhaagen, J. (2009) From microsurgery to nanosurgery: how viral vectors may help to repair the injured peripheral nerve. Prog. Brain Res. 175: 171-186
 
 Harvey, A.R., Ehlert, E.M.E., De Wit, J., Drummond, E., Pollett, M.A., Ruitenberg, M.J., Plant, G.W., Verhaagen, J., Levelt, C.N. (2009) Use of GFP to analyse morphology, connectivity and function of cells in the central nervous system. Methods Mol. Biol. 515: 63-95
 
MacGillavry, H.D., Stam, F.J., Sassen, M.M., Kegel, L., Hendriks, W.T.J., Verhaagen, J., Smit, A.B., Van Kestern, R.E. (2009) NFIL3 and cAMP Response Element-Binding Protein from a transcriptional feed forward loop that controls neuronal regeneration-associated gene expression. J. Neurosci. 29: 15542-15550
 
 Eggers, R.,Tannemaat, M.R., Ehlert, E.M., Verhaagen, J. (2009) A spatio-temporal analysis of motorneuron survival, axonal regeneration and neurotrophic factor expression after lumbar ventral root avulsion and implantation. Exp. Neurol., in press
 
Blits, B., Derks, S., Twisk, J., Ehlert, E.M., Prins, J., Verhaagen, J. (2009) Adeno-associated viral vector (AAV)-mediated gene transfer in the red nucleus of the adult rat brain: comparative analysis of the transduction properties of seven AAV serotypes and lentiviral vectors. J. Neurosci. Meth., in press
 
2008

Stam, F.J., Mason, M., Smit, A.B., Verhaagen, J. (2008). A meta-analysis of large scale gene expression studies on the injured PNS: towards elucidating the genetic networks underlying successful regeneration. In: Neural regeneration and repair: proteomics and genomics strategies (ed. H.W. Mueller), pp. 35-59
 
Bossers, K., Meerhoff, G., Balesar, R., Van Dongen, J., Kruse, C., Swaab, D.F., Verhaagen J. (2008) Analysis of gene expression in Parkinson's disease: possible involvement of neurotrophic support and axon guidance in dopaminergic cell death. Brain Pathology, May 8 Epub.
 
Franssen, E.H.P., Essing, A., De Bree, F.M., Ramon-Cueto, A., Verhaagen, J. (2008) Comparative gene expression analysis of olfactory ensheathing glia cells and Schwann cells indicated distinct tissue repair characteristics of olfactory ensheathing glia cells. Glia 56: 1285-1298
 
Eggers R., Hendriks W.T.J., Tannemaat, M., Hoeben, R., Boer, G.J., Carlstedt, T.D., Verhaagen J. (2008) Neuroregenerative effects of the reimplantation of genetically modified spinal roots following avulsion of the spinal motor nerve. Molec. Cell. Neurosci. 39: 105-117
 
Tannemaat, M.R., Eggers, R., Hendriks, W.T.J., De Ruiter, G.C.W., Van Heerikhuize, J.J., Pool, C.W., Malessy. M.J.A., Boer, G.J., Verhaagen, J. (2008) Differential effects of lentiviral vector-mediated overexpresison of NGF and GDNF on regenerating sensory and motor axons in the transected peripheral nerve. Eur. J. Neurosci., 28(8):1467-79
 
Tannemaat, M, Verhaagen, J. Malessy, M.J.A. (2008) Gene therapy to treat peripheral nerve injury. Neurological Res., in press
 
Vukovic, J., Ruitenberg, M.J., Roet, K., Franssen, E.H.P., Arulpragasam, A., Sasaki, T., Verhaagen, J., Harvey, A.R., Busfield, S.J., Plant, G.W. (2008) The glycoprotein fibulin-3 regulates morphology and motility of olfactory ensheathing cells in vitro. Glia, Sep 19 Epub
 
Verhaagen, J., Pasterkamp, R.J. (2008) Semaphorins. New Encyclopedia of Neuroscience (Elsevier), in press.
 
Blits, B., Verhaagen, J. (2008) Gene therapy for neurological disease. Encyclopedia of Neuroscience (Springer), in press.
 
Harvey, A.R., Ehlert, E.M.E., De Wit, J., Drummond, E., Pollett, M.A., Ruitenberg, M.J., Plant, G.W., Verhaagen, J., Levelt, C.N. (2008) Use of GFP to detect and image transduced cells and their connections in the central nervous system. In: GFP in biology (eds. Hicks, B.), in press
 
2007

Adams, M., Carlstedt, T., Cavanagh, J., Lemon, R.N., McKernan, R., Priestley, J.V., Raisman, G., Verhaagen, J. (2007) International spinal research trust research strategy III: A discussion document. Spinal Cord 45: 2-14
 
Tannemaat M., Boer G.J., Verhaagen, J., Malessy M. (2007). Genetic modification of human sural nerve segments results in enhanced expression of nerve growth factor. Neurosurgery 61: 1286-1296
 
De Wit, J., Verhaagen, J. (2007) Proteoglycans and the function of axon guidance molecules. Adv. Exp. Med. Biol. 600: 73-89
 
Stam, F.J., MacGillavry, H., Amstrong, N., De Gunst, M., Zhang, Y., van Kesteren, R., Smit, A.B., Verhaagen, J. Identification of candidate transcription factors involved in regenerative neurite outgrowth, Eur. J. Neurosci. 25: 3629 – 3637
 
Hendriks, W.T.J., Eggers, R., Verhaagen, J., Boer, G.J. (2007). Lenti-viral vector- mediated genetic modification of the neural scar: predominat transduction of astrocytes but not meningeal cells, J. Neurosci. Res. 85: 3041-3052
 
Zhang, Y., Zhang, X., Wu, D., Verhaagen, J., Richardson, P.M., Bo, X. (2007) PSA-NCAM expression in dorsal root entry zone by lentiviral vector mediated expression of polysialotransferease promotes regeneration of sensory axons into the spinal cord, Molecular Therapy 15: 1796-1804
 
Korecka, J.A., Verhaagen, J., Hol, E.M. (2007) Cellular replacement and gene therapy strategies for Parkinson’s and Alzheimer’s disease. Regenerative Medicine: 2: 425-446
 
Franssen, E.H.P., De Bree, F.M., Verhaagen, J. (2007) Olfactory ensheathing glia: their contribution to primary olfactory nervous system regeneration and their regenerative potentila following transplantation into the injured spinal cord. Brain Res. Rev.: 56: 236-258
 
Tannemaat, M.R., Korecka, J., Ehlert, E.M.E., Mason, M.R.J., van Duinen, S.G., Boer, G.J., Malessy, M.J.A., Verhaagen, J. (2007). Human neuroma contains increased levels of semaphorin3A, which surrounds nerve fibers and reduces neurite extension in vitro. J. Neuroscience 27: 14260-14264
 
2006

Hendriks, W.T.J., Eggers, R., Ruitenberg, M.J., Blits, B., Hamers, F.P.T., Verhaagen, J. and Boer, G.J. (2006) Profound differences in spontaneous long term functional recovery after defined spinal tract lesions in the rat. J.Neurotrauma 23: 18-35.
 
De Winter, F., Vo, T., Stam, F.J., Wisman L.A.B., Bar, P.R., Niclou, S.P., van Muiswinkel, F.L., Verhaagen, J. (2006) The expression of the chemorepellent semaphorin 3A is selectively induced in terminal Schwann cells of a subset of neuromuscular synapses that display a limited anatomical plasticity and enhanced vulnerability in motor neuron disease. Molec. Cell. Neurosci. 32: 102-117
 
De Wit, J., Eggers, R., Evers, R., Castren, E., Verhaagen, J. (2006) Long-term adeno-associated viral vector-mediated expression of truncated TrkB in adult rat facial nucleus results in motor neuron degeneration. J. Neuroscience 26: 1516-1530
 
Niclou, S.P., Ehlert, E., Verhaagen, J. (2006) Chemorepulsive guidance molecules in spinal cord injury. J. Neurotrauma 23: 409-421
 
Pasterkamp, R.J., Verhaagen, J. (2006) Semaphorins and axonal regeneration: developmental guidance cues gone wrong? Phil. Trans. R. Soc. (U.K.) 361: 1499-1511
 
De Wit, J. Toonen, R., Verhaagen, J., Verhage, M. (2006). Transport of Semaphorin3A is activity-dependent and differs between axons and dendrites. Traffic 7: 1-18
 
Leaver, S.G., Cui, Q., Plant G.W., Arulpragasam, A., Hisheh, S., Verhaagen, J., Harvey, A.R.(2006) AAV-mediated expression of CNTF promotes long-term survival and regeneration of adult rat retinal ganglion cells. Gene Therapy 13: 1328-1341
 
Harvey, A.R., Hu, Y., Leaver, S.G., Mellough, C.B., Park, K., Verhaagen, J., Plant, G.W., Cui, Q. (2006) Gene therapy and transplantation in CNS repair: the visual system. Prog. Retinal Eye Res. 25: 449-489
 
Tervonen, T.A., Ajamian, F., De Wit, J., Verhaagen, J., Catsren, E., Castren, M. (2006) Overexpression of truncated TrkB isoform increases the proliferation of neural progenitors. Eur. J. Neurosci. 24: 1277-1285
 
2005

De Wit, J., De Winter, F., Klooster, J., Verhaagen, J. (2005) Semaphorin3A displays a punctate distribution on the cell surface and interacts with proteoglycans in the extracellular matrix of neuronal cells. Molec. Cell. Neurosci. 29: 40-55
 
Hu, Y., Leaver, S.G., Plant, G.W., Hendriks, W.T.J., Niclou, S.P., Verhaagen, J., Harvey, A.R., Ciu, Q., (2005) Lentiviral vector-mediated transfer of ciliary neurotrophic factor to Schwann cells within reconstructed peripheral nerve grafts enhances survival and axonal regeneration of adult retinal ganglion cells, Molec. Therapy 11: 906-915
 
Jimenez, C., Stam, F.J., Wan Li, K, Gouwenbreg, Y., Hornshaw, M.P., De Winter, F., Verhaagen, J., Smit, A.B. (2005) Proteomics of the injured rat sciatic nerve reveals protein expression dynamics during regeneration. Molec. Cell. Proteomics 4: 120-132
 
Ruitenberg, M.J., Levinson, D.B., Voon Lee, S., Verhaagen, J., Harvey, A.R., Plant, G.W., (2005) NT-3 expression from engineered olfactory ensheathing glia promotes spinal sparing and regeneration. Brain 128: 839-853
 
Zhang, Y., Bo, X., Schloepfer, R., Holtmaat, A.J.D.G., Verhaagen, J., Emson, P.C., Lieberman, A.R., Anderson, P.N. (2005) Growth-associated protein GAP-43 nad L1 act synergistically to promote rgenerative growth of Purkinje cell axons in vivo. PNAS 102: 14883-14888
 
2004

Hendriks, W.T.J., Ruitenberg, M.J., Boer, G.J., Verhaagen, J. (2004) Viral vector-mediated gene transfer of neurotrophins to promote regeneration of the injured spinal cord. Progr. Brain Res. 146:451-476.
 
Dillon, T.E., Saldanha, J., Giger, R., Verhaagen, J., Rochlin, M.W. (2004) Sema3A regulates the timing of target contact by cranial sensory axons. J. Comp. Neurol. 470-13-24.
 
Ruitenberg, M.J., Blits, B., Dijkhuizen, P.A., te Beek, E.T., Bakker, A., van Heerikhuize, J.J., Pool, C.W., Hermens, W.T.J., Boer, G.J., Verhaagen, J. (2004) Adeno-associated viral vector-mediated gene transfer of brain-derived neurotrophic factor reverses atrophy of rubrospinal neurons following both acute and chronic spinal cord injury. Neurobiol. of Disease, 15: 394-406.
 
Ahmed, B., Chakravarthy, S., Eggers, R., Hermens, W.T.J.M.C., Zhang, J.Y., Niclou, S.P., Lévelt, C., Sablitzky, F., Anderson, P.N., Lieberman, A.R., Verhaagen, J. (2004) Efficient delivery of Cre-recombinase to neurons in vivo and stable transduction of neurons using adeno-associated and lentiviral vectors. BMC Neuroscience 5: 4.
 
Blits,B., Carlstedt,T.P., Ruitenberg,M.J., de Winter,F., Hermens,W.T.J.M.C., Dijkhuizen,P.A., Claasens,J.W.C., Eggers,R., van der Sluis,R., Tenenbaum,L., Boer,G.J., and Verhaagen,J., Rescue and sprouting of motoneurons following ventral root avulsion and reimplantation combined with intraspinal adeno-associated viral vector-mediated expression of glial cell line-derived neurotrophic factor or brain-derived neurotrophic factor., Exp. Neurol. 189 (2004) 303-316.
 
Kas, M.J.H., Tiesjema, B., van Dijk, G., Barner, K.M., Barsh, G.S., Ter Brake, O., Verhaagen, J., Adan, R.A.H. (2004) Induction of brain region specific forms of obesity by Agouti. J.Neurosci. 24: 10176-10181.
 
De Winter, F., Qui., C., Symons, N., Verhaagen, J., Harvey, A.H. (2004) Expression of Class-3 semaphorins and their receptors in the neonatal and adult rat retina. Investigative Ophthalmology and Visual Science 45: 4554 – 4562.
 
2003

Blits, B., Oudega, M., Boer, G.J., Bunge, M., Verhaagen, J. (2003) Adeno-associated viral vector-mediated neurotrophin gene transfer improves hindlimb function in the injured adults rat spinal cord. Neuroscience 118: 271-81.
 
Holtmaat, A.J.G.D., Gorter, J.A., De Wit, J., Tolner E.A., Spijker, S., Giger, R.J., Lopes da Silva, F.H., Verhaagen, J.Exp. Neurol. 182: 142-150. (2003) Transient downregulation of sema3A in a rat model for temporal lobe epilepsy: a novel molecular event potentially contributing to mossy fiber sprouting.
 
Niclou, S.P., Franssen, E., Ehlert, E.M.E., Taniguchi, M., Verhaagen, J. (2003) Meningeal cell-derived Semaphorin3A inhibits neurite outgrowth. Molec. Cell. Neurosci., 24: 902-912.
 
Shearer, M.C., Niclou, S.P., Brown, D., Asher, R.A., Holtmaat, A.J.G.D., Levine, J.M., Verhaagen, J., Fawcett, J.W. (2003) The astrocyte/meningeal cell interface is a barrier to neurite outgrowth which can be overcome by manipulation of inhibitory molecules or axonal signalling pathways. Molec. Cell Neurosci. 24: 913-925.
 
Ruitenberg, M.J., Plant, G.W., Hamers, F.P.T., Wortel, J., Blits, B., Dijkhuizen, P.A., Gispen, W.H., Boer, G.J., Verhaagen, J. (2003) Ex vivo adenoviral vector-mediated neurotrophin gene transfer to olfactory ensheathing glia: effects on rubrospinal tract regeneration, lesion size and functional recovery following implantation in the injured rat spinal cord. J. Neurosci. 23: 7045 - 70 58.
 
Eisch, A.J., Bolaños, C.A., de Wit, J., Simonak, R.D., Pudiak, C.M., Barrot, M., Verhaagen, J., Nestler, E.J. (2003) BDNF in the ventral midbrain-nucleus accumbens pathway: a role in depression. Biol. Psych. 54: 994-1005.
 
De Wit, J., Verhaagen, J. (2003) Role of semaphorins in the adult nervous system. Prog. Neurobiol. 71: 249-267.
 


2002

De Winter, F., Oudega, M., Lankhorst, A., Hamers, F.P.T., Blits, B., Ruitenberg, M.J., Pasterkamp, R.J., Gispen, W.H., Verhaagen, J. (2002) Injury-induced class 3 semaphorin expression in the rat spinal cord. Exp. Neurol. 175: 61-75.
 
Harvey, A.R., Kamphuis, W., Eggers, R., Symons, N.A., Blits, B., Niclou, S., Boer, G.J., Verhaagen, J. (2002) Intravitreal injection of adeno-associated viral vectors results in the transduction of different types of retinal neurons in neonatal and adult rats: a comparison with lentiviral vectors. Mol. Cell. Neurosci. 21: 141-157

Holtmaat, A.J.G.D., De Winter, F., De Wit, J., Gorter, J.A., Lopes da Silva, F.H., Verhaagen, J. (2002) Semaphorins: contributors to structural stability of hippocampal networks? In: Hofman, M.A., Boer, G.J., Holtmaat, A.J.G.D., Van Someren, E.J.W., Verhaagen, J., Swaab, D.F. (Eds.). Progress in Brain Research 138: 17-38
 
Blits, B., Boer, G.J., Verhaagen, J. (2002) Pharmacological, cell, and gene therapy strategies to promote spinal cord regeneration. Cell Transplantation 11: 593-613.
 
Eaton, M., Blits, B., Ruitenberg, M.J., Verhaagen, J., Oudega, M. (2002). Amelioration of chronic neuropathic pain after partial nerve injury by adeno-associated viral (AAV) vector-mediated over-expression of BDNF in the rat spinal cord. Gene Therapy 9: 1387-1395.

Ruitenberg, M.J., Boer, G.J., Verhaagen, J. (2002). Adeno-associated viral vectors as agents for gene delivery: towards application in disorders and trauma of the central nervous system. Methods 28: 182-194.
 
Ruitenberg, M.J. Plant, G.W., Christensen, C.L., Blits, B., Niclou, S., Harvey, A.R., Boer, G.J., Verhaagen, J. (2002) Viral vector-mediated expression in olfactory ensheathing glia implants in the lesioned rat spinal cord. Gene Therapy 9: 135-146.
 
Verwer, R.W.H., Hermens, W.T.J.M.C., Dijkhuizen, P.A., ter Brake, O., Baker, R.E., Salehi, A., Sluiter, A.A., Kok, M.J.M., Müller, L.J., Verhaagen, J. and Swaab., D.F. (2002) Slices of post-mortem brain tissue remain alive for several weeks in culture. FASEB J. 16: 54-60.
 


2001

Boer, G.J., van Esseveldt, K.E., Dijkhuizen, P.A., Hermens, W.T.J.M.C., te Beek, E.T., van Heerikhuize, J.J., van Poldervaart, H.A. and Verhaagen, J. (2001) Adenoviral vector-mediated expression of neurotrophin-3 increases the neuronal survival in suprachiasmatic nucleus grafts. Exp. Neurol. 169: 365-375.
 
Pasterkamp, R.J. and Verhaagen, J. (2001) Emerging roles for semaphorins in neural regeneration. Brain Res. Rev. 35: 36-54.
 
Pasterkamp, R.J., Anderson, P.N. and Verhaagen, J. (2001) Peripheral nerve injury fails to induce growth of lesioned ascending dorsal column axons into spinal cord scar tissue expressing the axon repellent Semaphorin 3A. Eur.J. Neurosci. 13: 457-471.
 
De Vrij, F.M.S., Sluijs, J.A., Gregori, L., Fisher, D.A., Hermens, W.T.J.M.C., Goldgaber, D., Verhaagen, J., Van Leeuwen, F.W., Hol, E.M. (2001) Mutant ubiquitin expressed in Alzheimer's disease causes neuronal death. FASEB J. 15: 2680-2688.

 

2000

Salehi, A., Ocampo, M., Verhaagen, J. and Swaab, D.F. (2000) P75 neurotrophin receptors in the nucleus basalis of Meynert in relation to age, sex and Alzheimer’s disease. Exp. Neurol. 161: 245-258.
 
Pasterkamp, R.J., Giger, R.J., Baker, R.E., Hermens, W.T.J.M.C., Verhaagen, J. (2000) Ectopic adenoviral vector-directed expression of Sema3A in organotypic spinal cord explants inhibits growth of primary sensory afferents. Dev. Biol. 220: 129-141.
 
Blits, B., Dijkhuizen, P.A., Hermens, W.T.J.M.C. Hermens, Esseveldt, L.E., Boer, G.J., Verhaagen, J. (2000). Use of adenoviral vectors and ex vivo transduced neurotransplants: towards promotion of neuroregeneration. Cell Transplantation 9: 169-178.
 
Blits, B., Dijkhuizen, P.A., Boer, G.J., Verhaagen, J. (2000) Intercostal nerve implants transduced with an adenoviral vector encoding neurotrophin-3 promote regrowth of injured rat corticospinal tract fibers and improve hindlimb function. Exp. Neurol. 164: 25-37.
 
Tenenbaum, L., Jurysta, F., Stathopoulos, A., Puschban, Z., Melas, C., Hermens, W.T.J.M.C., Verhaagen, J., Pichon, B., Velu, T., Levivier, M. (2000) Tropism of AAV-2 vectors for neurons of the globus pallidus. NeuroReport 11: 1-7.
 
Rochlin, W., O’Connor, R., Giger, R.J., Verhaagen, J., Farbman, A.I. (2000) Comparison of neurotrophin and repellent sensitivities of early embryonic geniculate and trigeminal axons. J. Comp. Neurol. 422: 579-593.
 


1999

Boer, G.J., Van Esseveldt, K.E., Van der Geest, B.A.M., Duindam, H., Rietveld, W.J. (1999) Vasopressin-deficient suprachiasmatic nucleus (SCN) grafts re-instate circadian rhythmicity. Neuroscience 89: 375-385.
 
Dijkhuizen, P.A. and Verhaagen, J. (1999) The use of neurotrophic factors to treat spinal cord injury: advantages and disadvantages of different delivery methods. Neurosci. Res. Comm. 24: 1-10.
 
Hassink, G.C., Van Esseveldt, K.E., Dijkhuizen, P.A., Verhaagen, J. and Boer, G.J. (1999) Ontogeny of neurotrophin receptor TrkC expression in the rat forebrain and anterior hypothalamus with emphasis on the suprachiasmatic nucleus. Neuroscience 92: 705-712.
 
Pasterkamp, R.J., Giger, R.J., Ruitenberg, M-J., Holtmaat, A.J.G.D., De Wit, J., De Winter, F. and Verhaagen, J. (1999) Expression of the gene encoding the chemorepellent semaphorin III is induced in the fibroblast component of neural scar tissue formed following injuries of adult but not neonatal CNS. Molec. Cell. Neurosci. 13: 143-166.
 
Hermens, W.T.J.M.C., Ter Brake, O., Dijkhuizen, P.A., Sonnemans, M.A.F., Grimm, D., Kleinschmidt, A. and Verhaagen, J. (1999) Purification of recombinant adeno-associated virus by iodixanol gradient ultracentrifugation allows rapid and reproducible preparation of vector stocks for gene transfer in the nervous system. Human Gene Therapy 10: 1885-1891.
 
Blits, B., Dijkhuizen, P.A., Carlstedt, T.P., Poldervaart, H., Schiemanck, S., Boer, G.J. and Verhaagen, J. (1999) Adenoviral vector-mediated expression of a foreign gene in peripheral nerve tissue bridges implanted in the injured peripheral and central nervous system. Exp. Neurol. 160: 256-267.
 
Holtmaat, A.J.G.D., Huizinga, C.T., Margolis, F.L., Gispen, W.H. and Verhaagen, J. (1999) Transgenic expression of B-50/GAP-43 in mature olfactory neurons triggers downregulation of native B-50/GAP-43 expression in immature olfactory neurons. Molec. Brain Res. 74: 197-207.
 
Pasterkamp, R.J., Ruitenberg, M.J. and Verhaagen, J. (1999) Semaphorins and their receptors in olfactory axon guidance. Cell. Molec. Biol. 45: 763-779.
 


1998

Van Esseveldt, K.E., Hermens, W.T.J.M.C., Verhaagen, J., Boer, G.J. (1998) Transgene expression in fetal brain grafts is maintained for 7 months after ex vivo adenoviral vector medieted gene transfer. Neurosci. Lett. 240: 116-120
 
Holtmaat, A.J.G.D., Oestreicher, A.B., Gispen, W.H. and Verhaagen, J. (1998) Manipulation of gene expression in the nervous system: application to the study of neurite outgrowth and neuroregeneration-related proteins. Brain Res. Rev. 26: 43-71
 
Giger, R.J., Pasterkamp, R.J., Holtmaat, A.J.G.D., Heinen, S., Verhaagen, J. (1998) Anatomical distribution of the chemorepellent semaphorin III/Collapsin-1 in adult rat and human brain: Predominant expression in structures of the olfactory-hippocampal pathway and motor system. J. Neurosci. Res. 52: 27-42
 
Baker, R.E., Dijkhuizen, P.A., Van Pelt, J., Verhaagen, J. (1998) Growth of pyramidal and nonpyramidal dendrites in long-term organotypic explants of neonatal rat neocortex chronically exposed to neurotrophin-3. Eur. J. Neurosci. 10: 1037-1044
 
Hermens, W.T.J.M.C. and Verhaagen, J. (1998) Viral vectors, tools for gene transfer in the nervous system. Prog. in Neurobiol. 55: 399-432
 
Hermens, W.T.J.M.C. and Verhaagen, J. (1998) Suppression of inflammation by dexamethasone prolongs adenoviral vector-mediated transgene expression in the facial nucleus of the rat. Brain Res. Bull. 47: 133-149
 
Dijkhuizen, P.A., Pasterkamp, R.J., Hermens, W.T.J.M.C., De Winter, F., Giger, R.J., Verhaagen, J. (1998) Adenoviral vector mediated gene transfer to injured rat peripheral nerve. J. Neurotrauma 15: 387-397
 
Pasterkamp, R.J., Giger, R.J., Verhaagen, J. (1998) Regulation of semaphorin III/collapsin-I gene expression during peripheral nerve regeneration. Exp. Neurol. 153: 313-327
 
Duckers, H.J., Van Dokkum, R.P., Verhaagen, J., Van Luijtelaar, E.L., Coenen, A.M., Lopes da Silva, F.H., Gispen, W.H. (1998) Neurotrophic ACTH4-9 analogue treatment normalizes electroencephalographic alterations in chronic experimental allergic encephalomyelitis. Eur. J. Neurosci. 10: 3709-3720.
 
Zhang, Y., Dijkhuizen, P.A., Anderson, P.N., Liebermann, A.R., Verhaagen, J. (1998) Neurotrophin-3 delivered via an adenoviral vector promotes the regeneration of dorsal root afferents into spinal cord of adult rats. J. Neurosci. Res. 54: 554-562
 
Salehi, A., Verhaagen, J., Swaab, D.F. (1998) Neurotrophin receptors in Alzheimer=s disease. Prog. Brain Res. 117: 71-89
 
Giger, R.J., Pasterkamp, R.J., Holtmaat, A.J.G.D., Verhaagen, J. (1998) Semaphorin III: role in neuronal development and structural plasticity. Prog. Brain Res. 117: 133-150
 
Pasterkamp, R.J., De Winter, F., Giger, R.J., Verhaagen, J. (1998) Role of the chemorepellent semaphorinD(III)/collapsin-1 in neuroregeneration? Prog. Brain Res. 117: 151-170
 
Pasterkamp, R.J., De Winter, F., Holtmaat, A.J.G.D., Verhaagen, J. (1998) Evidence for a role of the chemorepellent semaphorin III and its receptor neuropilin-1 in the regeneration of primary olfactory axons. J. Neurosci. 18: 9962-9976
 
Aarts, L.H.J., Schotman, P., Verhaagen, J., Schrama, L.H. and Gispen, W.H. (1998) The role of the neural growth-associated protein B-50/GAP-43 in morphogenesis. Adv. Exp. Med. Biol. 446: 85-106.
 


1997

Hermens, W.T.J.M.C., Giger, R.J., Holtmaat, A.J.G.D., Dijkhuizen, P.A., Houweling, D., Verhaagen, J. (1997) Transient gene transfer to neurons and glia: analysis of adenoviral vector performance in the CNS and PNS. J. Neurosci. Meth. 71: 85-98.
 
Van Esseveldt, K.E., Liu, R., Hermens, W.T.J.M.C., Verhaagen, J., Boer, G.J. (1997) Adenoviral vector-mediated gene transfer and neurotransplantation: possibilities and limitations in grafting of the fetal rat suprachiasmatic nucleus. J. Neurosci. Meth. 71: 113-124.
 
Duckers, H.J., Muller, H.J., Verhaagen, J., Nicolay, K., Gispen, W.H. (1997) Longitudinal in-vivo magnetic resonance imaging studies in experimental allergic encephalomyelitis: neurotrophic effect of neurotrophic treatment on cortical lesion development. Neuroscience 77: 1163-1173.
 
Holtmaat, A.J.G.D., Hermens, W.T.J.M.C., Sonnemans, M.A.F., Giger, R.J., Van Leeuwen, F.W., Kaplitt, M.G., Oestreicher, A.B., Gispen, W.H., Verhaagen, J. (1997) Adenoviral vector-mediated expression of B-50/GAP-43 induces alterations in the membrane organization of olfactory axon terminals in vivo. J. Neurosci. 17: 6575-6586.
 
Hermens, W.T.J.M.C. and Verhaagen, J. (1997) Adenoviral vector-mediated gene expression in the nervous system of immunocompetent Wistar and T-cell deficient nude rats: preferential survival of transduced astroglial cells in nude rats. Hum. Gene Therapy 8: 1049-1063.
 
Dijkhuizen, P.A., Hermens, W.T.J.M.C., Teunis, M., Verhaagen, J. (1997) Adenoviral vector directed expression of neurotrophin-3 in rat dorsal ganglion explants results in a robust neurite outgrowth response. J. Neurobiol. 33, 172-184.
 
Boer, G.J., Van Esseveldt, K.E., Hermens, W.T.J.M.C., Liu, R., Verhaagen, J. (1997) Longterm adenoviral vector directed gene expression in fetal rat SCN transplants. Exp. Neurol., 145: 536-545.
 
Oestreicher, A.B., De Graan, P.N.E., Verhaagen, J., Gispen, W.H. and Schrama, L.J. (1997) B50/GAP43: modulation of cell morphology and communication in the nervous system. Prog. in Neurobiol. 53: 627-686.
 
Buffo, A., Holtmaat, A.J.G.D., Savio, T., Verbeek, S., Oberdick, J.O., Oestreicher, A.B., Gispen, W.H., Verhaagen, J., Rossi, F., Strata, P. (1997) Targeted overexpression of the neurite growth-associated protein B-50/GAP-43 in cerebellar Purkinje cells induces sprouting in response to axotomy, but does not allow axon regeneration into growth permissive transplants. J. Neurosci. 17: 8778-8791.
 


1996

Duckers, H.J., Van Dokkum, R.P., Verhaagen, J., Van Luijtelaar, E.L., Coenen, A.M., Lopes da Silva, F.H., Gispen, W.H. (1996) Functional and neurophysiological evidence of the efficacy of trophic pharmacotherapy using an adrenocorticotrophic hormone4-9 analog in experimental allergic encephalomyelitis, an animal model of multiple sclerosis. Neuroscience 71: 507-521.
 
Holtmaat, A.J.G.D., Hermens, W.T.J.M.C., Oestreicher, A.B., Gispen, W.H, Kaplitt, M.G., Verhaagen, J. (1996) Efficient adenoviral vector directed expression of a foreign gene to neurons and sustentacular cells in the mouse olfactory neuroepithelium. Molec. Brain Res. 41: 148-156.
 
Salehi, A., Verhaagen, J., Dijkhuizen, P.A., Swaab, D.F. (1996) Colocalization of high affinity neurotrophin receptors in nucleus basalis of Meynert neurons and their differential reduction in Alzheimer's disease. Neuroscience 75: 373-387.

Giger, R.J., Wolfer, D.P., De Wit, G.M.J., Verhaagen, J. Anatomy of rat semaphorin- III/collapsin-1 mRNA expression and relationship to developing nerve tracts during neuroembryogenesis. J. Comp. Neurol. 375: 378-392.
 
Vogt, L., Giger, R.J., Ziegler, U., Kunz, B., Buchstaller, A., Hermens, W.T.J.M.C., Kaplitt, M.G., Rosenfeld, M.R., Pfaff, D.W., Verhaagen, J. and Sonderegger, P. (1996) Continuous renewal of the axonal pathway sensor apparatus by insertion of new sensor molecules into the growth cone membrane. Current Biology 6: 1153-1158.

Verhaagen, J., Hermens, W.T.J.M.C., Dijkhuizen, P.A., Holtmaat, A.J.G.D., Gispen, W.H. (1996) Use of viral vectors to promote neuroregeneration. Clin. Neurosci. 3: 275-283.

Hamers, F.P.T., Plantinga, L.-C., Verhaagen, J., Neijt, J.P., Gispen, W.-H. (1996) Upregulation of B50/GAP-43 protein mRNA in rat dorsal root ganglia during cisplatin intoxication. J. Neurosci. Res. 44: 142-148.

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