Ysbrand van der Werf
Born: 19-09-1971, Groningen
Highschool: 'Het Willem Lodewijk Gymnasium' Groningen (cum laude), The Netherlands 1983-1989
University: RijksUniversiteit Groningen, Master degree in 1. Biology (cum laude) and 2. Psychology 1989-1996
PhD: Graduate School Neurosciences Amsterdam, 1996-2000
Postdocs:
1. Dept Neuropsychology/Cognitive Neuroscience Unit, Montreal Neurological Institute, McGill University, Canada, 2000-2003
2. Dept Sleep&Cognition, Netherlands Institute for Neuroscience, 2003-2007
Currently:
1. Assistant Professor, 0.3 fte Dept Anatomy and Neurosciences, VU university medical center, Amsterdam.
2. Senior Researcher, 0.7fte, at the Netherlands Institute for Neuroscience, Dept Sleep&Cognition, Amsterdam.
Currently supervising and co-supervising 8 PhD candidates and 1 technician.
Co-promotor of Ellemarije Altena, graduated March 2010
Areas of expertise:
1. Mechanisms of memory formation and consolidation in humans
2. Sleep and wake states
3. Cognitive and emotional deficits in Parkinson's Disease
4. Functional neuroimaging (PET, aMRI, fMRI)
5. Signal analysis (EEG, MEG)
6. Neuromodulation (TMS, rTMS)
7. Neuropsychology/cognitive testing
Additional scientific activities:
1. Member 'De Jonge Akademie', a platform for young scientists in the Royal Netherlands Academy of Arts and Sciences. Participation in outreach and societal activities, member of steering group 'Concordat' in collaboration with VSNU.
2. Member autopsy team, Netherlands Brain Bank (NBB): assistance in obtaining post-mortem tissue from donors registered with the NBB
3. Co-organizer 2010 NIN-KNAW International Summerschool, Amsterdam
4. Lecturer for the 2003 summerschool of the 'Vivian Smith Advanced Studies Institute of the International Neuropsychological Society' of Memory and the Amnesias, 22 June - 19 July 2003, Xylocastro, Greece.
5. Lecturer for the 2004, 2005, 2006 courses in International Graduate Program Medical Neurosciences, Charité, Berlin Medical University.
6. Symposium organizer at Worldsleep07, 5th world sleep congress of the WFSRSMS, 3 September 2007, Cairns, Australia
7. Member executive committee International Society for Behavioural Neuroscience (ISBN), 2010 onwards
Selected research grants:
1. ‘De Jonge Akademie’ grant 2011, 12,000 euros,
2. ‘Parkinson vereniging’ 2011, 80,000 euros
3. Programmes for Excellence ‘Brain & Cognition: an Integrated Approach’, 2010, 500,000 euros
4. NeuroSIPE grant, STW perspective programme ‘diagnostic tools for neurological disorders’, 2009, 748,935 euros
5. VIDI grant, 966,469 euros, Netherlands Organization for Scientific Research (NWO), 2008
6. PhD grant, Neuroscience Campus Amsterdam, VUmc.
7. Jeanne Timmins Costello postdoctoral fellowship award, Montreal Neurological Institute, 2002, 25,000 CAD
8. Canadian Institutes for Health Research, postdoctoral fellowship award, 2002, 38,000 CAD
9. Postdoc fellowship stipend (‘TALENT stipendium’), 2002, 58,000 dutch guilders.
Selected references:
first/last-authored:
1. Van Den Heuvel OA, Van Gorsel H, Veltman DJ, Van Der Werf YD. Impairment of executive performance after transcranial magnetic modulation of the left dorsal frontal-striatal circuit. In press Human Brain Mapping
2. Van Der Werf YD, Altena E, Vis JC, Koene T, Van Someren EJW. Sleep loss affects vigilance. Effects of selective suppression of slow-wave activity. In press Progress in Brain Research
3. Van Der Werf YD, Sanz-Arigita EJ, Menning S, Van Den Heuvel OA. Regionally modulating resting-state cortical network activity using repetitive TMS: an offline rTMS - fMRI study. BMC Neuroscience 11:145, 2010.
4. Van Der Werf YD, Altena E, Van Dijk KD, Strijers RLM, De Rijke W, Stam CJ, Van Someren EJW. Is disturbed intracortical excitability a stable trait of chronic insomnia? A study using transcranial magnetic stimulation before and after multimodal sleep therapy. Biological Psychiatry, 68; 950-955, 2010.
5. Van Der Werf YD, Van Der Helm E, Schoonheim MM, Ridderikhoff A, Van Someren EJW. Learning by observation requires an early sleep window. Proc Natl Acad Sci U S A 106:18926-18930, 2009
6. Van Dijk KD, Møst EIS, Van Someren EJW, Berendse HW, Van Der Werf YD. Beneficial effect of transcranial magnetic stimulation on sleep in Parkinson’s disease, Movement Disorders 24;878-884, 2009.
7. Van Der Werf YD, Altena E, Schoonheim MM, Sanz-Arigita EJ, Vis JC, De Rijke W, Van Someren EJW. Slow-wave sleep benefits subsequent hippocampal functioning. Nature Neuroscience 12: 122-123, 2009
8. Van Der Werf YD, Berendse HW, Van Someren EJW, Stoffers D, Stam CJ, Wolters Ech. Observations on the cortical silent period in Parkinson’s Disease; a transcranial magnetic stimulation study. J Neural Transmission S72: 155-158, 2007
9. Van Der Werf YD, Paus T. The neural response to transcranial magnetic stimulation of the human motor cortex. I. Intracortical and cortico-cortical contributions. Exp Brain Res 175(2):231-245, 2006
10. Van Der Werf YD, Strafella AP, Sadikot AF, Paus T. The neural response to transcranial magnetic stimulation of the human motor cortex. II. Thalamocortical contributions. Exp Brain Res 175(2):246-255, 2006
11. Van Der Werf Y.D., Scheltens Ph, Lindeboom J., Witter M.P. Uylings H.B.M. and Jolles J. Neuropsychology of infarctions in the thalamus: 22 new cases. Neuropsychologia, 41(10), 1330-1344, 2003
12. Van Der Werf Y.D., Jolles J., Witter M.P. and Uylings H.B.M. Contributions of thalamic nuclei to memory functioning. Cortex, 39, 1047-1062, 2003
13. Van Der Werf Y.D., Witter M.P. and Groenewegen H.J. The intralaminar and midline nuclei of the thalamus. Anatomical and functional evidence for participation in processes of arousal and awareness. Brain Research Reviews, 39, 107-140, 2002
14. Van Der Werf Y.D., Tisserand DJ, Visser PJ, Hofman PAM, Vuurman E, Uylings HBM and Jolles J. Thalamic volume predicts performance on tests of cognitive speed and decreases in healthy aging. A magnetic resonance imaging-based volumetric analysis. Cognitive Brain Research; 11,377-385,2001
15. Van Der Werf Y.D., Witter M.P., Uylings H.B.M. and Jolles J. Neuropsychology of infarctions in the thalamus: a review. Neuropsychologia; 38(5), 613-627, 2000
16. Van Der Werf Y.D., Weerts J.G.E., Jolles J., Witter M.P., Lindeboom J. and Scheltens Ph., Neuropsychological correlates of a right unilateral lacunar thalamic infarction. Journal of Neurology, Neurosurgery and Psychiatry 66, 36-42, 1999
17. Witter M.P. and Van Der Werf Y.D. The medial dorsal nucleus of the thalamus is not a part of a hippocampal-thalamic memory system. Behavioral and Brain Sciences, 22 (3) 467-468, 1999
other:
18. Hulst HE, Schoonheim MM, Roosendaal SD, Popescu V, Schweren LJS, Van Der Werf YD, Visser LH, Polman CH, Barkhof F, Geurts JJG. Functional adaptive changes within the hippocampal memory system of multiple sclerosis patients. In press Human Brain Mapping
19. Van den Heuvel OA, Zwitser G, Mataix-Cols D, Cath DC, Van Der Werf, YD, Groenewegen HJ, Van Balkom AJLM, Veltman DJ. Common limbic and frontal-striatal disturbances in patients with obsessive compulsive disorder, panic disorder and hypochondriasis. In press Psychological Medicine
20. Hindriks R, Bijma F, Van Dijk BW, Stam CJ, Van Der Werf YD, Van Someren EJW, Van Der Vaart A. Data-driven modeling of phase interactions between spontaneous MEG oscillations . Human Brain Mapping, 32; 1161-1178, 2011.
21. Hindriks R, Bijma F, Van Dijk BW, Stam CJ, Van Der Werf YD, Van Someren EJW, Van Der Vaart A. Dynamics underlying spontaneous human alpha oscillations: a data-driven approach. NeuroImage 57; 440-451, 2011.
22. Altena, E, Ramautar JR, Van Der Werf YD, Van Someren EJW. Do sleep complaints contribute to age-related cognitive decline? Progress in Brain Research 185; 181-205, 2010.
23. Van Den Heuvel OA, Van Der Werf YD, Verhoef KMW, DE Wit S, Berendse HW, Wolters ECh, Veltman DJ, Groenewegen HJ. Frontal-striatal abnormalities underlying behaviours in the compulsive-impulsive spectrum. Journal of the Neurological Sciences 289:55-59; 2010
24. Altena E, Vrenken H, Van Der Werf YD, Van Den Heuvel OA, Van Someren EJW. Reduced orbitofrontal and parietal grey matter in chronic insomnia: a voxel-based morphometric study. Biological Psychiatry 67:182-185 2010
25. Altena E, Van Der Werf YD, Sanz Arigita EJ, Voorn T, Rombouts SARB, Kuijer JPA, Van Someren EJW. Prefrontal hypoactivation and recovery in insomnia. Sleep 31: 1271-1276, 2008
26. Wolters, ECh, Van Der Werf YD, Van Den Heuvel OA. Parkinson’s Disease-related disorders in the impulsive-compulsive spectrum. J Neurol 255 Suppl 5: 51-59, 2008
27. Altena E, Van Der Werf YD, Strijers RLM, Van Someren EJW. Sleep loss affects vigilance. Effects of chronic insomnia and sleep therapy. J Sleep Res 17: 335-343, 2008
28. Strafella AP, Vanderwerf Y, Sadikot AF. Effects of transcranial magnetic stimulation of the human motor cortex on subthalamic neuronal activity. Eur J Neurosci, 20(8): 2245-2249, 2004
29. Chouinard P.A., Van Der Werf Y.D., Leonard G. and Paus T. Modulation of neural networks induced by low-frequency transcranial magnetic stimulation of the dorsal premotor and primary motor cortices: a TMS/PET study. Journal of Neurophysiology, 90, 1071-1083, 2003
30. Visser P.J., Krabbendam L., Verhey F.R.J., Hofman P.A.M., Verhoeven W.M.A., Tuinier S., Wester A., Van Den Berg Y.W.M.M., Goessens L.F.M., Van Der Werf Y.D. and Jolles J. Brain correlates of memory dysfunction in alcoholic Korsakoff’s syndrome. Journal of Neurology, Neurosurgery and Psychiatry; 67, 774-778, 1999
31. Postigo J.A., Van Der Werf Y.D., Korf J. and Krugers H.J., Altered expression of the cell cycle regulatory protein cyclin D1 in the rat dentate gyrus after adrenalectomy-induced granular cell loss. Neuroscience Letters 241, 107-110, 1998
32. Van Dijk G., De Groote C., Chavez M., Van Der Werf Y., Steffens A.B. and Strubbe J.H., Insulin in the arcuate nucleus of the hypothalamus reduces fat consumption in rats. Brain Research 777, 147-152, 1997