PERSONAL DATA
Name: Ling Shan
Nationality: China

Contact
Netherlands Institute for Neuroscience
Meibergdreef 47, 1105 BA Amsterdam
The Netherlands
Phone Numbers
Tel. +31.20.5665500
Email: L.shan@nin.knaw.nl

Education

2007, Master (Science, Zhejiang University School of Medicine, China). Project: Molecular determinants of NMDA receptor assembly analyzed by                 fluorescence resonance energy transfer (FRET).

11/2007-04/2012, Ph.D. student (Netherlands institute for Neuroscience, Amsterdam, The Netherlands. Supervisors: Prof. Dr. Dick F. Swaab and Prof. Dr. Ai-Min Bao) Project: the histaminergic system in neuropsychiatric disorders: a post-mortem study.

04/2012-03/2013, Post doctoral training Project: the epigenetic mechanisms underlying the ‘for-better-and-for-worse’ outcomes of serotonin transporter gene x environment interactions.

Part time working experience

09/2010-Present,  Autopsy assistant of Netherlands Brain Bank 

Skills

Immunocytochemistry;

In-situ hybridization (radiation safe handling diploma),

Human/ rodent brain neuroanatomy

Plasmid construction and cell transfection

Cell imagining acquisition and data analysis

Data analysis by SPSS and Matlab (periodic)

Behavior (animal handling diploma (article 9 (NL)) 

RNA-sequencing and Epigenetic measurements

List of publications

(_* indicating authors contributed equally, IF = Impact factor)

1.      Liu CQ *, Shan L *, Balesar R, Luchetti S, van Heerikhuize J, Luo JH, Swaab DF and Bao A-M.  A quantitative in situ hybridization protocol for formalin-fixed paraffin-embedded archival postmortem human brain tissue. Methods. 2010 Dec;52(4):359-66. PMID: 20621191 IF: 4.5.

2.      van Wamelen DJ*, Shan L *, Aziz NA, Anink JJ, Bao AM, Roos RA, Swaab DF. Functional Increase of Brain Histaminergic Signaling in Huntington's Disease. Brain Pathology 2011 Jul;21(4):419-27. PMID: 21106039 IF:4.7.

3.      Shan L *, Liu CQ*, van Heerikhuize J, Bao A M and Swaab D F. Neuronal    histamine production remains unaltered in Parkinson’s disease despite the accumulation of Lewy bodies and Lewy neurites in the tuberomamillary nucleus Neurobiology of Aging. 2012 Jul;33(7):1343-4. PMID:21371786 IF:6.6.

4.      Shan L, Bossers K, Bao A M and Swaab D F. Alterations in the histaminergic system in the substantia nigra and striatum of Parkinson’s patients: a postmortem study. Neurobiology of Aging 2012 Jul;33(7):1488.e1-13. PMID: 22118942 IF:6.6.

5.      Shan L, Hofman M., van Wamelen D J., Van Someren E J.W., Bao A M, and Swaab D F. Diurnal fluctuation in histidine decarboxylase expression, the rate limiting enzyme for histamine production, and its disorder in neurodegenerative diseases. Sleep. 2012 May 1;35(5):713-5.PMID: 22547898 IF:5.6.

6.      Shan L, Bossers K, Unmehopa U, Bao A-M and Swaab D F.. Alterations in the histaminergic system in Alzheimer’s disease: a postmortem study. Neurobiology of Aging  2012 Nov; 33(11) 2585–2598 PMID: 22284987 IF: 6.6.

7.      Shan L, Swaab D F., Bao A-M. Neuronal histaminegic system in aging and age-related neurodegenerative disorders. Experimental gerontology 2012 Aug 11. [Epub ahead of print] PMID:22910064 IF 3.7. 

8.      Shan L, Qi X-R, Balesar R., Swaab D F., and Bao A-M Unchanged histaminergic system  in depression: a postmortem study. Journal of Affective Disorders 2012 Sep 28. [Epub ahead of print] IF 3.5.

9.      Qiu S, Zhang XM, Cao JY, Yang W, Yan YG, Shan L, Zheng J, Luo JH.An endoplasmic reticulum retention signal located in the extracellular amino-terminal domain of the NR2A subunit of N-Methyl-D-aspartate receptors. J Biol Chem 2009 284(30): 20285-98 PMID: 19487695 IF: 5.3.

10.  Wilhelmus M. M., Verhaar R, Andringa G, Bol JG, Cras P, Shan L, Hoozemans JJ. M., Drukarch B. Presence of Tissue Transglutaminase in Granular Endoplasmic Reticulum is Characteristic of Melanized Neurons in Parkinson's Disease Brain. Brain pathology 2011 Mar; 21(2):130-9. PMID:20731657 IF:4.7.