Synapse and Network Development

The development of specific synaptic connections between nerve cells is a fundamental step during the maturation of the brain, but its underlying mechanisms are largely unknown. To investigate how neurons establish specific connections, we apply high resolution imaging and electrophysiology in brain slices and in vivo.

Our goal is to identify patterns of neuronal activity, forms of calcium signaling and molecular factors that regulate synapse development. We focus on the local regulation of synapse maturation and its relationship with activity patterns in the entire cell and the emerging network.



The SND group receives an NWO VICI grant for the project ”Preparing the brain for vision: how spontaneous activity wires the developing visual system before eye opening".



Special Symposium

Neuronal Plasticity

Thursday, August 21st 2014

NIN Colloquium room


Yevgenia Kozorovitskiy

Rewarding connections: Neuromodulatory state-dependent plasticity in striatal development


Thomas Nevian

Plasticity in the anterior cingulate cortex induced by neuropathic pain


Tara Keck

Homeostatic plasticity in mouse visual cortex in vivo


Special Lecture

Heinz Beck

Wednesday, September 24th 2014

NIN Colloquium room