Publications

Elimination of inhibitory synapses is a major component of adult ocular dominance plasticity.
van Versendaal D, Rajendran R, Saiepour MH, Klooster J, Smit-Rigter L, Sommeijer JP, De Zeeuw CI, Hofer SB, Heimel JA, Levelt CN.
Neuron. 2012 Apr 26;74(2):374-83.

Synaptotagmin-2 is a reliable marker for parvalbumin positive inhibitory boutons in the mouse visual cortex.
Sommeijer JP, Levelt CN.
PLoS One. 2012;7(4):e35323.

Critical-Period Plasticity in the Visual Cortex.
Levelt CN, Hübener M.
Annu Rev Neurosci. 2012 Mar 29. [Epub ahead of print]

Candidate genes in ocular dominance plasticity.
Rietman ML, Sommeijer JP; Neuro-Bsik Mouse Phenomics Consortium, Levelt CN, Heimel JA.
Front Neurosci. 2012;6:11. Epub 2012 Feb 1.

The role of GABAergic inhibition in ocular dominance plasticity.
Heimel JA, van Versendaal D, Levelt CN.
Neural Plast. 2011:391763. Epub 2011 Aug 2. Review.

The synaptic proteome during development and plasticity of the mouse visual cortex.
Dahlhaus M, Li KW, van der Schors RC, Saiepour MH, van Nierop P, Heimel JA, Hermans JM, Loos M, Smit AB, Levelt CN.
Mol Cell Proteomics. 2011 May;10(5):M110.005413. E

Structure and function relationships during ocular dominance plasticity in the visual cortex.
Dahlhaus M, Levelt CN.
Rev Neurosci. 2010;21(3):223-37. Review.

Contrast gain control and cortical TrkB signaling shape visual acuity.
Heimel JA, Saiepour MH, Chakravarthy S, Hermans JM, Levelt CN.
Nat Neurosci. 2010 May;13(5):642-8. Epub 2010 Apr 18.

Use of GFP to analyze morphology, connectivity, and function of cells in the central nervous system.
Harvey AR, Ehlert E, de Wit J, Drummond ES, Pollett MA, Ruitenberg M, Plant GW, Verhaagen J, Levelt CN.
Methods Mol Biol. 2009;515:63-95.

A genetically encoded calcium indicator for chronic in vivo two-photon imaging.
Mank M, Santos AF, Direnberger S, Mrsic-Flogel TD, Hofer SB, Stein V, Hendel T, Reiff DF, Levelt C, Borst A, Bonhoeffer T, Hübener M, Griesbeck O.
Nat Methods. 2008 Sep;5(9):805-11.

Notch1 signaling in pyramidal neurons regulates synaptic connectivity and experience-dependent modifications of acuity in the visual cortex.
Dahlhaus M, Hermans JM, Van Woerden LH, Saiepour MH, Nakazawa K, Mansvelder HD, Heimel JA, Levelt CN.
J Neurosci. 2008 Oct 22;28(43):10794-802.

Cre-dependent expression of multiple transgenes in isolated neurons of the adult forebrain.
Chakravarthy S, Keck T, Roelandse M, Hartman R, Jeromin A, Perry S, Hofer SB, Mrsic-Flogel T, Levelt CN.
PLoS One. 2008 Aug 26;3(8):e3059.

Genetic control of experience-dependent plasticity in the visual cortex.
Heimel JA, Hermans JM, Sommeijer JP; Neuro-Bsik Mouse Phenomics consortium, Levelt CN.
Genes Brain Behav. 2008 Nov;7(8):915-23. Epub 2008 Aug 12.

Screening mouse vision with intrinsic signal optical imaging.
Heimel JA, Hartman RJ, Hermans JM, Levelt CN.
Eur J Neurosci. 2007 Feb;25(3):795-804.

Postsynaptic TrkB signaling has distinct roles in spine maintenance in adult visual cortex and hippocampus.
Chakravarthy S, Saiepour MH, Bence M, Perry S, Hartman R, Couey JJ, Mansvelder HD, Levelt CN.
Proc Natl Acad Sci U S A. 2006 Jan 24;103(4):1071-6. Epub 2006 Jan 17.

Activation of the Notch pathway in Down syndrome: cross-talk of Notch and APP.
Fischer DF, van Dijk R, Sluijs JA, Nair SM, Racchi M, Levelt CN, van Leeuwen FW, Hol EM.
FASEB J. 2005 Sep;19(11):1451-8.

Disruption of Abcc6 in the mouse: novel insight in the pathogenesis of pseudoxanthoma elasticum.
Gorgels TG, Hu X, Scheffer GL, van der Wal AC, Toonstra J, de Jong PT, van Kuppevelt TH, Levelt CN, de Wolf A, Loves WJ, Scheper RJ, Peek R, Bergen AA.
Hum Mol Genet. 2005 Jul 1;14(13):1763-73. Epub 2005 May 11.

Structural plasticity in the developing visual system.
Bence M, Levelt CN.
Prog Brain Res. 2005;147:125-39. Review.

Crumbs homologue 1 is required for maintenance of photoreceptor cell polarization and adhesion during light exposure.
van de Pavert SA, Kantardzhieva A, Malysheva A, Meuleman J, Versteeg I, Levelt C, Klooster J, Geiger S, Seeliger MW, Rashbass P, Le Bivic A, Wijnholds J.
J Cell Sci. 2004 Aug 15;117(Pt 18):4169-77.

Stress priming in picture naming: an SOA study.
Schiller NO, Fikkert P, Levelt CC.
Brain Lang. 2004 Jul-Sep;90(1-3):231-40.

Efficient delivery of Cre-recombinase to neurons in vivo and stable transduction of neurons using adeno-associated and lentiviral vectors.
Ahmed BY, Chakravarthy S, Eggers R, Hermens WT, Zhang JY, Niclou SP, Levelt C, Sablitzky F, Anderson PN, Lieberman AR, Verhaagen J.
BMC Neurosci. 2004 Jan 30;5:4.

Early activation of TCR alpha gene rearrangement in fetal thymocytes.
Rytkönen-Nissinen M, Hurwitz JL, Pelkonen S, Levelt C, Pelkonen J.
Eur J Immunol. 1999 Jul;29(7):2288-96.

High- and low-affinity single-peptide/MHC ligands have distinct effects on the development of mucosal CD8alphaalpha and CD8alphabeta T lymphocytes.
Levelt CN, de Jong YP, Mizoguchi E, O'Farrelly C, Bhan AK, Tonegawa S, Terhorst C, Simpson SJ.
Proc Natl Acad Sci U S A. 1999 May 11;96(10):5628-33.

Inhibition of intrathymic T cell development by expression of a transgenic antagonist peptide.
Levelt CN, Mizoguchi E, Huang X, Zacks R, Bhan AK, Tonegawa S.
Proc Natl Acad Sci U S A. 1998 Nov 24;95(24):14349-54.

CD16-expressing CD8alpha alpha+ T lymphocytes in the intestinal epithelium: possible precursors of Fc gammaR-CD8alpha alpha+ T cells.
She J, Simpson SJ, Gupta A, Holländer G, Levelt C, Liu CP, Allen D, van Houten N, Wang B, Terhorst C.
J Immunol. 1997 May 15;158(10):4678-87.

Immature T cells in peripheral lymphoid organs of recombinase-activating gene-1/-2-deficient mice. Thymus dependence and responsiveness to anti-CD3 epsilon antibody.
Falk I, Potocnik AJ, Barthlott T, Levelt CN, Eichmann K.
J Immunol. 1996 Feb 15;156(4):1362-8.

Receptors and signals in early thymic selection.
Levelt CN, Eichmann K.
Immunity. 1995 Dec;3(6):667-72. Review. No abstract available.

Regulation of thymocyte development through CD3: functional dissociation between p56lck and CD3 sigma in early thymic selection.
Levelt CN, Mombaerts P, Wang B, Kohler H, Tonegawa S, Eichmann K, Terhorst C.
Immunity. 1995 Aug;3(2):215-22.

T lymphocyte development in p56lck deficient mice: allelic exclusion of the TcR beta locus is incomplete but thymocyte development is not restored by TcR beta or TcR alpha beta transgenes.
Wallace VA, Kawai K, Levelt CN, Kishihara K, Molina T, Timms E, Pircher H, Penninger J, Ohashi PS, Eichmann K, et al.
Eur J Immunol. 1995 May;25(5):1312-8.

Regulation of T cell receptor (TCR)-beta locus allelic exclusion and initiation of TCR-alpha locus rearrangement in immature thymocytes by signaling through the CD3 complex.
Levelt CN, Wang B, Ehrfeld A, Terhorst C, Eichmann K.
Eur J Immunol. 1995 May;25(5):1257-61.

Wang B, Levelt C, Salio M, Zheng D, Sancho J, Liu CP, She J, Huang M, Higgins K, Sunshine MJ, et al.
Int Immunol. 1995 Mar;7(3):435-48.

Transcription of granzyme A and B genes is differentially regulated during lymphoid ontogeny.
Ebnet K, Levelt CN, Tran TT, Eichmann K, Simon MM.
J Exp Med. 1995 Feb 1;181(2):755-63.

Selection of peripheral and intestinal T lymphocytes lacking CD3 zeta.
Simpson S, Holländer G, She J, Levelt C, Huang M, Terhorst C.
Int Immunol. 1995 Feb;7(2):287-93.

Streptavidin-tricolor is a reliable marker for nonviable cells subjected to permeabilization or fixation.
Levelt CN, Eichmann K.
Cytometry. 1994 Jan 1;15(1):84-6.

Lineage relationships of the fetal thymocyte subset that expresses the beta chain of the interleukin-2 receptor.
Falk I, Levelt CN, Eichmann K.
Eur J Immunol. 1993 Dec;23(12):3373-6.

Restoration of early thymocyte differentiation in T-cell receptor beta-chain-deficient mutant mice by transmembrane signaling through CD3 epsilon.
Levelt CN, Mombaerts P, Iglesias A, Tonegawa S, Eichmann K.
Proc Natl Acad Sci U S A. 1993 Dec 1;90(23):11401-5.

Regulation of thymocyte development through CD3. II. Expression of T cell receptor beta CD3 epsilon and maturation to the CD4+8+ stage are highly correlated in individual thymocytes.
Levelt CN, Carsetti R, Eichmann K.
J Exp Med. 1993 Dec 1;178(6):1867-75.

Involvement of the complement system in the pathogenesis of pulmonary leukostasis in experimental myelocytic leukemia.
van Buchem MA, Levelt CN, Hogendoorn PC, Colly LP, Kluin PM, Willemze R, Daha MR.
Leukemia. 1993 Oct;7(10):1608-14.

Regulation of thymocyte development through CD3. I. Timepoint of ligation of CD3 epsilon determines clonal deletion or induction of developmental program.
Levelt CN, Ehrfeld A, Eichmann K.
J Exp Med. 1993 Mar 1;177(3):707-16.

Development of pulmonary leukostasis in experimental myelocytic leukemia in the Brown-Norway rat.
van Buchem MA, Hogendoorn PC, Levelt CN, van Hengel P, Colly LP, Kluin PM, Willemze R.
Leukemia. 1992 Feb;6(2):142-9.

Text/HTML