Axons provide the wiring to connect neurons and also rapidly generate and conduct the action potential, the fundamental basis of fast electrical signalling in the nervous system. Because of their small diameters, however, little is understood about their precise electrical properties. Using electrophysiological methods, high-resolution imaging and computational methods our group studies action potential conduction and axonal voltage-gated ion channels directly in the neocortical primary axon. The aim of this research is to unravel the functional contribution of voltage-gated channels to signal conduction, axonal computations and in particular to understand their role in neuron-glia mediated myelination.
This work is funded by the European Research Council under the European Community's Seventh Framework Programme (FP7), ERC - Starting Grant #261114.