Biosketch

I was trained in biology with a minor in physics and received a cum laude Masters degree in Biology. I did my PhD in the laboratory of Medical Physics in the Faculty of Medicine of the University of Amsterdam and my postdoctoral research at the University of California at Berkeley with  Frank Werblin. I received the prestigious KNAW-fellowship after my return to the Netherlands. This allowed me to establish the Retinal Signal Processing lab which was initially located in the Netherlands Ophthalmic Research Institute (NORI) and later moved to the Netherlands Institute for Neuroscience (NIN) of the KNAW.

 

The theme leading my research is: Form Light Detection to Vision. The photoreceptors are the light sensitive neurons in the retina. They detect light. However, vision is much more than just detecting light. The image falling onto the retina needs a lot of processing before it can be percieved. This processing starts in the retina. The retina is a highly sofisticated image analysis device. It selects and compresses relevant information in a scene before it is send to the brain. I am facinated by the elegance of these processing steps. Resolving the functioning of the retina and using this fundamental knowlegde to develope strategies to help blind people motivates me enormously.

 

I am a professor in Neurophysiology specialized in Sensory Physiology at the Academic Medical Center (AMC) of the University of Amsterdam (UvA). My ~60 peer-reviewed publications in scientific journals, including Science, Neuron, PLoS Biology and American journal of Human Genetics, have been widely cited in the field. My exploration of the visual sensory system is characterized by a highly multidisciplinary approach and often with a strong quantitative signature. This is reflected in the composition of The Retinal Signal Processing lab, which is fully staffed and equipped for this broad approach, ranging from genetics/molecular biology, morphology to single cell electrophysiology/vital imaging information theory and behavior.

Peer Reviewed Publications

  • Duco Endeman*, Iris Fahrenfort*, Trijntje Sjoerdsma, Marvin Steijaert, Huub ten Eikelder and Maarten Kamermans (2012) Chloride Currents in Cones Modify Feedback from Horizontal Cell to Cones in Goldfish Retina J. Physiol http://www.ncbi.nlm.nih.gov/pubmed/22890705?dopt=Citation
  • Lauw Klaassen, Iris Fahernfort and Maarten Kamermans (2012) Connexin Hemichannel Mediated Ephaptic Inhibition in the Retina Brain Res http://dx.doi.org/10.1016/j.brainres.2012.04.059. [PDF]
  • Ziyi Sun, Dao-Qi Zhang, Maarten Kamermans, and Douglas G. McMahon (2012) Differential Contributions of Two Connexins to Zebrafish Retinal Horizontal Cell Hemichannel Currents J Neuophysiology 107(10): 2624-2632. [PDF]
  • Neal S. Peachey, Thomas A. Ray, Ralph Florijn, Lucy B. Rowe, Trijntjes Sjoerdsma, Susana Contreras-Alcantara, Kenkichi Baba, Gianluca Tosini, Nikita Pozdeyev, P. Michael Iuvone, Pasano Bojang Jr., Jillian N. Pearring, Huibert Jan Simonsz, Mies van Genderen, David G. Birch, Elias I. Traboulsi, Allison Dorfman, Irma Lopez, Huanan Ren, Andrew F.X. Goldberg, Patsy M. Nishina, Pierre Lachapelle, Maureen A. McCall, Robert K. Koenekoop, Arthur A.B. Bergen, Maarten Kamermans*, Ronald G. Gregg* (2012) GPR179 is required for depolarizing bipolar cell function and is mutated in autosomal recessive complete congenital stationary night blindness. Am J Human Gen 90:331-339. [PDF]
  • Jan Klooster, Joyce Blokker, Jacoline B. ten Brink, Unga Unmehopa,Kees Fluiter, Arthur A.B. Bergen, Maarten Kamermans (2011)Ultrastructureal localization and expression of TRPM1 in the human retina Investigative Ophthalmology and Visual Science 52(11):8356-8362. [PDF]
  • Lauw Klaassen, Ziyi Sun, Marvin N. Steijaert, Petra Bolte, Iris Fahrenfort, Trijntje Sjoerdsma, Jan Klooster, Yvonne Claassen, Colleen Shields, Huub M. M. Ten Eikelder, Ulrike Janssen-Bienhold, Georg Zoidl, Douglas McMahon, Maarten Kamermans(2011) Synaptic Transmission from Horizontal Cells to Cones is Impaired by Loss of Connexin Hemichannels PLoS Biology 9(7): e1001107. doi:10.1371/journal.pbio.1001107. [PDF]
  • Paul R. Kasher, Yasmin Namavar, Paula van Tijn, Kees Fluiter, Aleksander Sizarov, Maarten Kamermans, Andrew J. Grierson, Danica Zivkovic and Frank Baas (2011) Impairment of the tRNA splicing endonuclease subunit 54 (tsen54) gene causes neurological abnormalities and larval death in zebrafish models of Pontocerebellar Hypoplasia Human Molecular Genetics 20 (8):1574-1584. [PDF]
  • M. Kamermans and C. Hawryshyn (2011) Teleost Polarisation Vision: How it works and what it's good for. Phil. Trans. R. Soc. B366:742-756. [PDF]
  • D. Endeman and M. Kamermans. (2010) Cones perform a nonlinear transformation on natural stimuli. J. Physiol 588:435-446. [PDF]
  • H.J. Simonsz, R. Florijn, H.M. van Minderhout, A.A.B. Bergen, M. Kamermans. (2009) Nightblindness-Associated Transient Tonic Downgaze (NATTD) in Infant Boys with Chin-up Head Posture Strabismus 17(4):158-164. [PDF]
  • Mies M. van Genderen, Mieke M.C. Bijveld, Yvonne B. Claassen, Ralph J. Florijn, Jillian N. Pearring, Francoise M. Meire, Maureen A. McCall, Frans C.C. Riemslag, Ronald G. Gregg, Arthur A.B. Bergen, Maarten Kamermans. (2009) Mutations in TRPM1 are a common cause of complete congenital stationary night blindness. Am J Human Gen 85(5):730-736. [PDF] [PDF Comments]
  • Iris Fahrenfort, Marvin Steijaert, Trijntje Sjoerdsma, Evan Vickers, Harris Ripps, Jorrit van Asselt, Duco Endeman, Jan Klooster, Robert Numan, Huub ten Eikelder, Henrique von Gersdorff and Maarten Kamermans(2009) Feedback from horizontal cells to cones in the vertebrate retina PLoSOne 4(6):e6090. [PDF]
  • Nora Prochnow, Sarah Hoffmann, Rozan Vroman, Jan Klooster, Stefanie Bunse, Maarten Kamermans, Rolf Dermietzel,Georg Zoidl (2009) Pannexin1 in the outer retina of the zebrafish, Danio rerio Neurosci 162(4):1039-1054. [PDF]
  • M. VanLeeuwen, I. Fahrenfort, T. Sjoerdsma, R. Numan, M. Kamermans. (2009) Lateral gain control in the outer retina leads to potentiation of center responses of retinal neurons J Neurosci 29(19):6358-6366. [PDF]
  • Yin Shen, J. Alexander Heimel, Maarten Kamermans, Neal S. Peachey, Ronald G. Gregg and Scott Nawy (2009) A transient receptor potential-like channel mediates synaptic transmission in rod bipolar cells. J Neurosci 29(19):6088-6093. [PDF] [PDF Comments]
  • Jan Klooster, Stephen Yazulla, Maarten Kamermans(2009)Ultrastructural analysis of the glutamatergic system in the outer plexiform layer of zebrafish retina J Chem Neuroanatmy 37(4):254-265. [PDF]
  • C. Jocelevitch, M. Kamermans. (2009) Retinal Parallel Pathways: Seeing With Our Inner Fish. Vision Res 49(9):943-959. [PDF]
  • Mahboob-ul-hussain, Georg Zoidl, Jan Klooster, Maarten Kamermans and Rolf Dermietzel. (2008) Evidence for the internal translation of a carboxy-terminal domain of the neuronal connexin zfCx55.5: An IRES element in the coding region makes the translation possible. BMC. Mol. Biol. 9:52. [PDF]
  • S. Ramsden, L. Anderson, M. Mussi, T. Haimberger, M. Kamermans, C. Hawryshyn (2008) Retinal processing and opponent mechanisms mediating ultraviolet polarization sensitivity in rainbow trout (Oncorhynchus mykiss) J. Exp. Biol. 211:1376-1385. [PDF] [PDF Comments]
  • Leanne Godinho, Philip R. Williams, Yvonne Claassen, Elayne Provost, Steven D. Leach, Maarten Kamermans and Rachel O. L. Wong. (2007) In vivo imaging reveals novel modes of horizontal cell genesis in the developing zebrafish retina. Neuron 56(4):587-603. [PDF] [PDF preview]
  • Ronald G. Gregg, Maarten Kamermans, Jan Klooster, Peter D. Lukasiewicz, Neal S. Peachey, Kirstan A. Vessey, Maureen A. McCall (2007) Bipolar cell expression of nyctalopin restores visual function in mice with congenital stationary night blindness. J Neurphysiol 98(5): 3023-3033. [PDF]
  • C. Joselevitch, Jan Klooster and M. Kamermans (2007) Localization of metabotropic glutamate receptors in the outer retina of goldfish. Cell and Tissue Research ­330(3): 389-403. [PDF]
  • M. van Leeuwen, C. Joselevitch, I. Fahrenfort and M. Kamermans. (2007) The contribution of the outer retina to color constancy: a general model synthesized from primate and fish data. Vis Neurosci 24:1-14. [PDF]
  • C. Shields, J. Klooster, Y. Claassen, Mahboob-ul-hussain, Georg Zoidl, R. Dermietzel and M. Kamermans. (2007) Horizontal cells-specific expression of connexin 52.6 & connexin 55.5 in the zebrafish retina. J. Comp Neurol 501:765-779. [PDF]
  • C. Joselevitch and M. Kamermans (2007) Interaction between rod and cone inpus in mixed-input bipolar cells in the goldfish retina. J. Neurosci Res 85(7):1579-1591. [PDF]
  • Mieke L. Struik, Stephen Yazulla, Maarten Kamermans (2006) Cannabinoid agonist WIN 55212-2 speeds up the cone light offset response. Vis Neurosci 23:285-293. [PDF]
  • Fahrenfort I, Klooster J, Sjoerdsma T, Kamermans M (2005) The involvement of glutamate-gated channels in negative feedback from horizontal cells to cones. Prog Brain Res 147: 219-229. [PDF]
  • Fahrenfort I, Sjoerdsma T, Ripps H, Kamermans M (2004) Cobalt ions inhibit negative feedback in the outer retina by blocking hemichannels on horizontal cells. Vis Neurosci 21: 501-511. [PDF]
  • Kamermans M, Fahrenfort I (2004) Ephaptic interactions within a chemical synapse: hemichannel-mediated ephaptic inhibition in the retina. Curr Opin Neurobiol 14: 531-541. [PDF]
  • Klooster J, Nunes CB, Yazulla S, Kamermans M (2004) Postsynaptic localization of gamma-aminobutyric acid transporters and receptors in the outer plexiform layer of the goldfish retina: An ultrastructural study. J Comp Neurol 474: 58-74. [PDF]
  • M. Kamermans, D.A. Kraaij and H. Spekreijse (2001) The dynamics of the signal from horizontal cells to cones in the goldfish retina. J Physiol 534(2): 489-500 [PDF]
  • C.A.V. Vandenbranden, W. Kamphuis, B. Nunes Cardozo and M. Kamermans (2001) Immunocytochemical localization of glutamate receptor subunits in the goldfish retina. J Neurocytol 29(10):729-742. [PDF]
  • M. Kamermans, I. Fahrenfort, K. Schultz, U. Janssen-Bienhold, T. Sjoerdsma and R. Weiler (2001) Hemichannel mediated inhibition in the outer retina. Science 292: 1178-1180 [PDF}
  • P. Hardus, W.M. Verduin, M. Kamermans, G. Postma, J.S. Stilma, T.T.J.M. Berendschot and C.W.M. van Veelen (2001) The value of electrophysiological results in patients with epilepsy and vigabatrin associated visual field loss. Acta Ophthal Scan 79:169-174 [PDF}
  • D.A.Kraaij, H., Spekreijse and M. Kamermans (2000) The open and closed loop characteristics of the cone/horizontal cell synapse in goldfish retina J Neurophysiol 84: 1256-1265 [PDF]
  • C.A.V. Vandenbranden, S. Yazulla, K. Studholm, W. Kamphuis and M. Kamermans (2000) Immunolocalization of the glutamate transporter GLT-1 in the goldfish (Carassius auratus) retina. J Comp Neurol 423(3):440-451 [PDF]
  • D.A. Kraaij, H. Spekreijse and M. Kamermans (2000) The nature of surround induced depolarizing responses in goldfish cones. J Gen Physiol 115:1-14 [PDF]
  • Fahrenfort, R. Habets, H. Spekreijse and M. Kamermans (1999) Light-induced short-term potentiation of the cone-horizontal cell synapse in goldfish retina. J Gen Physiol 114:511-524 [PDF]
  • T. Sjoerdsma, M. Kamermans and H. Spekreijse (1999) Effect of the tuberculostaticum ethambutol and stimulus intensity on chromatic discrimination in man. Vision Res 39(17):2955‑2962 [PDF]
  • M. Kamermans and H. Spekreijse (1999) The feedback pathway from horizontal cells to cones in the goldfish retina. A mini review with a look ahead. Vision Res 39(15):2449‑2468 [PDF]
  • M. Kamermans, D.A. Kraaij and H. Spekreijse (1998) The Cone/Horizontal cell network: A possible site for color constancy. Vis Neurosci 15:787-797 [PDF]
  • D.A. Kraaij, M. Kamermans and H. Spekreijse (1998) The spectral sensitivity of the feedback signal from horizontal cells to cones in the goldfish retina. Vis Neurosci 15:799-808 [PDF]
  • J. Verweij, M. Kamermans, K. Negishi and H. Spekreijse (1998) GABA sensitivity of spectrally classified horizontal cells in goldfish retina. Vis Neurosci 15:77-86 [PDF]
  • J. Bhattacharjee, B. Nunes Cardozo, W. Kamphuis, M. Kamermans and G. F. J. M. Vrensen (1997) Pseudo-immunolabelling with the Avidin-Biotin-Peroxidase Complex (ABC) due to the presence of endogenous biotin in retinal Müller cells of goldfish and salamander. J Neurosci Meth 77:75-82 [PDF]
  • M. Kamermans and H. Spekreijse (1996) The dynamics of the outer retina. A functional description based on morphology, physiology and neural modelling. Vision Res 36(24):3857-3858 [PDF]
  • J. Verweij, M. Kamermans, E.C. van den Aker and H. Spekreijse (1996) Modulation of horizontal cell receptive fields in the light adapted goldfish retina. Vision Res 36(24):3913-3923 [PDF]
  • J. Verweij, M. Kamermans and H. Spekreijse (1996) Horizontal cells feedback to cones by shifting the cone calcium current activation range. Vision Res 36(24):3943-3953 [PDF]
  • M. Kamermans, J. Haak, J.B.A. Habraken and H. Spekreijse (1996) The size of the horizontal cell receptive fields adapts to the stimulus in the light adapted retina. Vision Res 36(24):4105-4119 [PDF]
  • C.A.V. Vandenbranden, J. Verweij, M. Kamermans, L.J. Müller, J.M. Ruijter, G.F.J.M. Vrensen and H. Spekreijse (1996) Clearance of neurotransmitters from the synaptic cleft of goldfish retina. Vision Res 36(24):3859-3874 [PDF]
  • T. Sjoerdsma, M. Kamermans and H. Spekreijse (1996) The effect of ethambutol and stimulus intensity on wavelength discrimination in goldfish. Vision Res 36(21):3519-3523 [PDF]
  • J.J. Wietsma, M. Kamermans and H. Spekreijse (1995) Horizontal cells function normally in ethambutol-treated goldfish. Vision Res 35(12):1667-1674 [PDF]
  • M. Kamermans and H. Spekreijse (1995) Spectral coding of cone-driven horizontal cells in teleost retina. Prog in Ret and Eye Res 14(1):313-360 [PDF]
  • M. Kamermans and F.S. Werblin (1992) GABA-Mediated positive autofeedback loop controls horizontal cell kinetics in tiger salamander retina. J Neurosci 12(7):2451-2463 [PDF]
  • M. Kamermans, B.W. van Dijk and H. Spekreijse (1991) Color opponency in cone driven horizontal cells in carp retina; Aspecific pathways between cones and horizontal cells. J Gen Physiol 87:819-843 [PDF]
  • M. Kamermans, B.W. van Dijk and H. Spekreijse (1990) Interaction between the soma and axon terminal of retinal horizontal cells. Vision Res 30:1011-1016 [PDF]
  • M. Kamermans, B.W. van Dijk and H. Spekreijse (1989) Lateral feedback from monophasic horizontal cells to cones in carp retina. II: A quantitative model. J Gen Physiol 93: 695-714 [PDF]
  • M. Kamermans, B.W. van Dijk, H. Spekreijse and R.C.V.J. Zweypfenning (1989) Lateral feedback from monophasic horizontal cells to cones in carp retina. I: Experiments. J Gen Physiol 93: 681-694 [PDF]
  • N.A.M. Schellart, M. Kamermans and L.J.A. Nederstigt (1987) An electrophy­si­ologi­cal study of the topographical organization of the multisensory torus semicircularis of the rainbow trout. Comp Biochem Physiol 88A: 461-469 [PDF]
  • T. Zuidema, M. Kamermans and J. Siegenbeek van Heukelom (1986) Influence of glucose absorption on ion activities in cells and submucosal space in goldfish intestine. Pflügers Arch 407: 292-298 [PDF]

PhD Thesis, Books, and Contributions to Books

  • Het zien van het onvoorspelde – Het onvoorspelde van het zien. M. Kamermans. Vossiuspers UvA Amsterdam (2009) ISBN: 978 90 5629 578 3. e-ISBN: 978 90 4851 084 9. [PDF]
  • Development, dynamics and pathology of neural networks: From molecules to functional circuits. Progress in Brain research: 147. (2004) Elsevier. Edited by: J. van Pelt, M. Kamermans, C.N. Levelt, A. van Ooyen, G.J.A. Ramakers en P.R. Roelfsema.
  • M. Kamermans, I. Fahrenfort, T. Sjoerdsma and J. Klooster (2003) GABAergic modulation of ephaptic feedback in the outer retina. In: The Neural Basis of Early Vision. Tokyo. [PDF]
  • M. Kamermans, B.W. van Dijk, H. Spekreijse and F.S. Werblin (1991) A model for the changes in coupling and kinetics of cone driven retinal horizontal cells during light/dark adaptation. In: Proceedings of Analysis and Modeling of Neural Systems. Berkeley, July 25-27, 1990 [PDF]
  • M. Kamermans, B.W. van Dijk and H. Spekreijse (1989) Carp responses of color coded ganglion cells evoked by current injection into horizontal cells. Neurobiol. of the inner retina. Nato ASI Series. Ed. R. Weiler and N.N. Osborne. Springer Verlag. Vol. H31:503-512. [PDF]
  • M. Kamermans (1989) The functional organization of the horizontal cell layers in carp retina. PhD thesis. University of Amsterdam. Rodopi, Amsterdam [PDF]
  • J. Siegenbeek van Heukelom, T. Zuidema and M. Kamermans (1986) The role of the structure of epithelial compartments in transepithelial transport. In: Ion Gradient-Coupled Transport; INSERM Symp. No. 26. Editors: F. Alvorado and C.H. van Os, Elsevier Science Publishers B.V. 249-252