How do the anatomical connections and neurotransmitters used by the biological clock (SCN) control the daily release pattern of hormones and the activity of the autonomic nervous system? Read more

The hypothalamic arcuate nucleus expresses both orexigenic and anorexigenic peptides that play a key role in the central regulation of food intake and energy metabolism. Read more

To ensure glucose homeostasis, a multilevel network in the hypothalamus modulates glucose production, as well as glucose disposal. Read more

A major function of thyroid hormones is the regulation of lipid and carbohydrate metabolism. Read more

Anti-psychotic drugs, as well as a number of anti-epileptic drugs, are known to cause weight gain and a complex of metabolic changes, including insulin resistance. Read more

Tracing studies in our group proved the existence of neural pathways between the brain and different WAT compartments and showed that separate neurons in the brainstem and hypothalamus are in control of either subcutaneous or intra-abdominal WAT. Read more

Previous research has mainly focused on the control of the hypothalamus in hepatic glucose metabolism, whereas evidence shows that it also plays a role in hepatic lipid metabolism. Read more

The hypothalamus controls daily rhythms in hormone release and energy metabolism through three pathways: the pituitary, and the parasympathetic and sympathetic branches of the autonomic nervous system (ANS). Read more

It is well established that the autonomic nervous system plays a crucial role in the detection, integration and response to peripheral inflammation and/or infection. Read more