Our aim: To elucidate the pathobiology of complex neuro-ophthalmic disorders, including age-related macular degeneration (AMD) and retinitis pigmentosa (RP).  Fundamental research into the molecular machinery and function of the retina(l pigment epithelium) is instrumental for this purpose.

Our research questions: Why do we loose vision as we age? What are the common denominators of retina and brain disease? What are the specific molecular and cellular mechanisms underlying age-related macular degeneration and other genetically determined neuro-ophthalmic disorders? Can we, ultimately, develop a rational genomics-driven prevention or therapy for these disorders?

 
Our experimental approach: Depending on the research question(s) asked, we study human patients, human (patient) material, cell lines or transgenic mouse models with a range of  in silico, molecular, cellular or functional techniques and methodologies. Typically, we follow a genomics driven approach, from molecule to man.

 
Our Ophthalmogenetics centre: Together with the departments of ophthalmology and clinical genetics of the AMC, we form a strong international ophthalmogenetic centre, in which ophthalmogenetic research, education and patient care are combined. Cornerstone of this centre is the presence of a unique register/biobank of over 22.000 patients with genetic eye disorders, which is held by the NIN since 1965.

 
Our collaborations: We interact substantially with several (inter-)national research groups, which provide complementary resources, expertise(s) or interests.