Mission

The Netherlands Institute for Neuroscience (NIN) carries out fundamental neuroscience research with special emphasis on the brain and the visual system. Our research focusses on development, plasticity and ageing and it is often linked to clinical research questions.

 

The scientific structure comprises three levels of biological complexity:

  • genetic and molecular approaches
  • cellular approaches and network function
  • system approaches

 

The research program is carried out in 20 research groups.
In addition, the NIN includes the Netherlands Brain Bank

 

Scientific Director Pieter R. Roelfsema, PhD
Vice Director Chris I. de Zeeuw, PhD
Managing Director Ronald van der Neut, PhD

 

 

 

Recent publications

Stanisor, L., Van der Togt, C., Pennartz, C.M., and Roelfsema, P.R. A unified selection signal for attention and reward in primary visual cortex. PNAS, in press. [abstract]
   

Badura, A., Schonewille, M., Voges, K., Galliano, E., Renier, N., Gao, Z., Witter, L., Hoebeek, F.E., Chédotal, A., and De Zeeuw, C.I. Climbing fiber input shapes reciprocity of Purkinje cell firing. Neuron, in press. [abstract]
     

Orre, M., Kamphuis, W., Dooves, S.,  Kooijman, L., Chan, E.T., Kirk, C.J., Dimayuga Smith, V., Koot, S., Mamber, C., Jansen, A.H., Ovaa, H., and Hol, E.M. Reactive glia show increased immunoproteasome activity in Alzheimer's disease. Brain 136 (2013) 1415-1431. [abstract]
  

Dudok, J.J., Sanz Sanz, A., Lundvig, D.M.S., and Wijnholds, J. MPP3 is required for maintenance of the apical junctional complex, neuronal migration and stratification in the developing cortex. Journal of Neuroscience 33 (2013) 8518-8527. [abstract]
   

Kessels, H.W., Nabavi, S., and Malinow, R. Metabotropic NMDA receptor function is required for β-amyloid-induced synaptic depression. PNAS 110 (2013) 4033-4038. [abstract]
     

Nabavi, S., Kessels, H.W., Alfonso, S., Aow, J., Fox, R., and Malinow, R. Metabotropic NMDA receptor function is required for NMDA receptor-dependent long-term depression. PNAS 110 (2013) 4027-4032. [abstract]

Figee, M.,  Luigjes, J., Smolders, R., Valencia-Alfonso, C.E., Van Wingen, G., De Kwaasteniet, B., Mantione, M., Ooms, P., De Koning, P.,  Vulink, N., Levar, N., Droge, L., Van den Munckhof, P.,  Schuurman, P.R., Nederveen, A., Van den Brink, W.,  Mazaheri, A., Vink, M., and Denys, D. Deep brain stimulation restores frontostriatal network activity in obsessive-compulsive disorder. Nature Neuroscience, in press. [abstract]

 

Cuadrado, E., Jansen, M.H., Anink, J., De Filippis, L., Vescovi, A.L., Watts, C., Aronica, E., Hol, E.M., and Kuijpers, T.W. Chronic exposure of astrocytes to interferon-α reveals molecular changes related to Aicardi-Goutières syndrome. Brain 136 (2013) 245-258. [abstract]

 

Verhoeven, V.J.M., Hysi, P.G., Wojciechowski, R., Fan, Q., Guggenheim, J.A., Höhn, R., MacGregor, S., ……, Gorgels,T.G.M.F., ……, Bergen, A.A.B., Vitart, V., Baird, P.N., Wong,T.Y., Teo,Y.Y., Oexle, K., Mackey, D.A., Young, T.L., Van Duijn, C.M., Saw,S.M., Bailey Wilson, J.E., Stambolian, D., Klaver, C.C., and Hammond, C.J. Genome-wide meta-analyses of multi-ethnic cohorts identify multiple new susceptibility loci for refractive error and myopia. Nature Genetics 45 (2013) 314-318. [abstract]

    

Piantoni, G., Poil, S.S., Linkenhaer-Hansen, K., Verweij, M., Ramautar, J.R., Van Someren, E.J.W., and Van der Werf, Y.D. Individual differences in white matter diffusion affect sleep oscillations. Journal of Neuroscience 33 (2013) 227-233. [abstract]

 

Alves, C.H., Sanz, A.S., Park, B., Pellissier, L.P., Tanimoto, N., Beck, S.C., Huber, G., Murtaza, M., Richard, F., Gurubaran, I.S., Garrido, M.G., Levelt, C.N., Rashbass, P., Le Bivic, A., Seeliger, M.W., and Wijnholds, J. Loss of CRB2 in the mouse retina mimics human retinitis pigmentosa due to mutations in the CRB1 gene. Human Molecular Genetics 22 (2013) 35-50. [abstract]

 

Fitzsimons, C.P., Van Hooijdonk, L.W.A., Schouten, M., Zalachoras, I., Brinks, V., Zheng, T., Schouten, T.G., Saaltink, D.J., Dijkmans, T., Steindler, D.A., Verhaagen, J., Verbeek, F.J., Lucassen, P.J., De Kloet, E.R., Meijer, O.C., Karst, H., Joels, M., Oitzl, M.S., and Vreugdenhil, E. Knockdown of the glucocorticoid receptor alters functional integration of newborn neurons in the adult hippocampus and impairs fear-motivated behavior. Molecular Psychiatry, in press. [abstract]

 

Stewart, S.E., Yu, D., Scharf, J.M., Neale, B.M., ............., Denys, D., Blom, R., ............, Singleton, A. for the North American Brain Expression Consortium, Hardy, J. for the UK expression Database, Crenshaw, A.T., Parkin, M.A., Mirel, D.B., Conti, D.V., Purcell, S., Nestadt, G., Hanna, G.L., Jenike, M.A., Knowles, J.A., Cox, N., and Pauls, D.L. Genome-wide association study of obsessive-compulsive disorder. Molecular Psychiatry, in press. [abstract]

 

More publications 

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News

6 May 2013
  
Elly Hol receives k€300 funding from ZonMW (More Knowledge with Fewer Animals programme) for a project on human adult neural stem cells.
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29 April 2013: Spinoza Centre:

The Spinoza Centre for Neuroimaging website has gone live. A button has been placed on web page of our institute. Please visit www.spinozacentre.nl to see what the Spinoza Centre is all about.
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17 April 2013. In the news:     

Elly Hol on Alzheimer Research [pdf]
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2 April 2013.
Recent paper of Joanna Korecka selected by the Media Outreach Program of IOS Press to be brought to the attention of the media.[press release]
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27 February 2013.
Joost Verhaagen receives the Schellenberg Prize 2013 from the International Foundation for Research in Paraplegia.
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14 February 2013.
Christiaan Levelt and Maarten Kamermans receive funding in the ALW Open Programme.
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1 February 2013

Christian Lohmann receives a VICI grant from NWO.

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26 January 2013. In the news:Joost Verhaagen and Martijn Malessy.

Progress in neural repair: from robotics to molecular neurosurgery. [pdf]

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10 January 2013, Persbericht KNAW: Nederlands Herseninstituut is nieuwe naam voor NIN-KNAW[persbericht

 


NINnews May 2012 
              

NINnews October 2011 

 

NINnews April2011

 

NINnews November2010 

 

NINnews June 2010

 

More

Events

29 May 2013, 11:30 h, Queridozaal ErasmusMC

Laurens Witter will defend his thesis entitled:
Whole cell recordings of the cerebellum in vivo.
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4 June 2013, 10:00 h, Agnietenkapel
   
Ji Liu will defend his thesis entitled:
  
The role of estrogen in hypothalamic regulation of hypothalamus-pituitary-adrenal axis activity, energy homeostasis and bone metabolism.


Gestart op 20 januari 2012
Groot nationaal Slaaponderzoek
bezoek de website en doe mee!

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