Mission

The Netherlands Institute for Neuroscience (NIN) carries out fundamental neuroscience research with special emphasis on the brain and the visual system. Our research focusses on development, plasticity and ageing and it is often linked to clinical research questions.

 

The scientific structure comprises three levels of biological complexity:

  • genetic and molecular approaches
  • cellular approaches and network function
  • system approaches

 

The research program is carried out in 20 research groups.
In addition, the NIN includes the Netherlands Brain Bank

 

Scientific Director Pieter R. Roelfsema, PhD
Vice Director Chris I. de Zeeuw, PhD
Managing Director Ronald van der Neut, PhD

 

 

 

Recent publications

Badura, A., Schonewille, M., Voges, K., Galliano, E., Renier, N., Gao, Z., Witter, L., Hoebeek, F.E., Chédotal, A., and De Zeeuw, C.I. Climbing fiber input shapes reciprocity of Purkinje cell firing. Neuron, in press. [abstract]
     

Orre, M., Kamphuis, W., Dooves, S.,  Kooijman, L., Chan, E.T., Kirk, C.J., Dimayuga Smith, V., Koot, S., Mamber, C., Jansen, A.H., Ovaa, H., and Hol, E.M. Reactive glia show increased immunoproteasome activity in Alzheimer's disease. Brain, in press. [abstract]
  

Dudok, J.J., Sanz Sanz, A., Lundvig, D.M.S., and Wijnholds, J. MPP3 is required for maintenance of the apical junctional complex, neuronal migration and stratification in the developing cortex. Journal of Neuroscience, in press.
   

Kessels, H.W., Nabavi, S., and Malinow, R. Metabotropic NMDA receptor function is required for β-amyloid-induced synaptic depression. PNAS 110 (2013) 4033-4038. [abstract]
     

Nabavi, S., Kessels, H.W., Alfonso, S., Aow, J., Fox, R., and Malinow, R. Metabotropic NMDA receptor function is required for NMDA receptor-dependent long-term depression. PNAS 110 (2013) 4027-4032. [abstract]

Figee, M.,  Luigjes, J., Smolders, R., Valencia-Alfonso, C.E., Van Wingen, G., De Kwaasteniet, B., Mantione, M., Ooms, P., De Koning, P.,  Vulink, N., Levar, N., Droge, L., Van den Munckhof, P.,  Schuurman, P.R., Nederveen, A., Van den Brink, W.,  Mazaheri, A., Vink, M., and Denys, D. Deep brain stimulation restores frontostriatal network activity in obsessive-compulsive disorder. Nature Neuroscience, in press. [abstract]

 

Cuadrado, E., Jansen, M.H., Anink, J., De Filippis, L., Vescovi, A.L., Watts, C., Aronica, E., Hol, E.M., and Kuijpers, T.W. Chronic exposure of astrocytes to interferon-α reveals molecular changes related to Aicardi-Goutières syndrome. Brain 136 (2013) 245-258. [abstract]

 

Verhoeven, V.J.M., Hysi, P.G., Wojciechowski, R., Fan, Q., Guggenheim, J.A., Höhn, R., MacGregor, S., ……, Gorgels,T.G.M.F., ……, Bergen, A.A.B., Vitart, V., Baird, P.N., Wong,T.Y., Teo,Y.Y., Oexle, K., Mackey, D.A., Young, T.L., Van Duijn, C.M., Saw,S.M., Bailey Wilson, J.E., Stambolian, D., Klaver, C.C., and Hammond, C.J. Genome-wide meta-analyses of multi-ethnic cohorts identify multiple new susceptibility loci for refractive error and myopia. Nature Genetics, in press.

    

Piantoni, G., Poil, S.S., Linkenhaer-Hansen, K., Verweij, M., Ramautar, J.R., Van Someren, E.J.W., and Van der Werf, Y.D. Individual differences in white matter diffusion affect sleep oscillations. Journal of Neuroscience 33 (2013) 227-233. [abstract]

 

Alves, C.H., Sanz, A.S., Park, B., Pellissier, L.P., Tanimoto, N., Beck, S.C., Huber, G., Murtaza, M., Richard, F., Gurubaran, I.S., Garrido, M.G., Levelt, C.N., Rashbass, P., Le Bivic, A., Seeliger, M.W., and Wijnholds, J. Loss of CRB2 in the mouse retina mimics human retinitis pigmentosa due to mutations in the CRB1 gene. Human Molecular Genetics 22 (2013) 35-50. [abstract]

   

Liu, X., Zhao, X., Zeng, X., Bossers, K., Swaab, D.F., Zhao, J., and Pei, G. β-Arrestin1 regulates γ-secretase complex assembly and modulates amyloid-β pathology. Cell Research, in press. [abstract
  

Peters, J.C., Roelfsema, P.R., and Goebel, R. Task-relevant and accessory items in working memory have opposite effects on activity in extrastriate cortex. Journal of Neuroscience 32 (2012) 17003-17011. [abstract]  
    

Gao, Z., Todorov, B., Barrett, C.F., Van Dorp, S., Ferrari, M.D., Van den Maagdenberg, A.M., De Zeeuw, C.I., and Hoebeek, F.E. Cerebellar ataxia by enhanced CaV2.1 currents is alleviated by Ca2+-dependent K+-channel activators Cacna1aS218L mutant mice. Journal of Neuroscience 32 (2012) 15533-15546. [abstract]  
   

Baudouin, S.J., Gaudias, J., Gerharz, S., Hatstatt, L., Zhou, K., Punnakkal, P., Tanaka, K.F., Spooren, W., Hen, R., De Zeeuw, C.I., Vogt, K., and Scheiffele, P. Shared synaptic pathophysiology in syndromic and nonsyndromic rodent models of autism. Science 338 (2012) 128-132. [abstract]

 

Fitzsimons, C.P., Van Hooijdonk, L.W.A., Schouten, M., Zalachoras, I., Brinks, V., Zheng, T., Schouten, T.G., Saaltink, D.J., Dijkmans, T., Steindler, D.A., Verhaagen, J., Verbeek, F.J., Lucassen, P.J., De Kloet, E.R., Meijer, O.C., Karst, H., Joels, M., Oitzl, M.S., and Vreugdenhil, E. Knockdown of the glucocorticoid receptor alters functional integration of newborn neurons in the adult hippocampus and impairs fear-motivated behavior. Molecular Psychiatry, in press. [abstract]

 

Zylberberg, A., Ouellette, B., Sigman, M., and Roelfsema, P.R. Decision making during the psychological refractory period. Current Biology, in press. [abstract]

 

Sorger, B., Reithler, J., Dahmen, B., and Goebel, R. A real-time fMRI-based spelling device immediately enabling robust motor-independent communication. Current Biology 22 (2012) 1333-1338. [abstract]
 

Tamietto, M., Pullens, P., De Gelder, B., Weiskrantz, L., and Goebel, R. Subcortical connections to human amygdala and changes following destruction of the visual cortex. Current Biology 22 (2012) 1449-1455. [abstract]

 

Gao, Z., Van Beugen, B.J., and De Zeeuw, C.I. Distributed synergistic plasticity and cerebellar learning. Nature Reviews Neuroscience 13 (2012) 619-635. [abstract]

 

Stewart, S.E., Yu, D., Scharf, J.M., Neale, B.M., ............., Denys, D., Blom, R., ............, Singleton, A. for the North American Brain Expression Consortium, Hardy, J. for the UK expression Database, Crenshaw, A.T., Parkin, M.A., Mirel, D.B., Conti, D.V., Purcell, S., Nestadt, G., Hanna, G.L., Jenike, M.A., Knowles, J.A., Cox, N., and Pauls, D.L. Genome-wide association study of obsessive-compulsive disorder. Molecular Psychiatry, in press. [abstract]

 

Gazzola, V., Spezio, M.L., Etzel, J.A., Castelli, F., Adolphs, R., and Keysers, C. Primary somatosensory cortex discriminates affective significance in social touch. PNAS 109(2012) E1657-E1666. [abstract]

  

Poort, J., Raudies, F., Wannig, A., Lamme, V.A.F., Neumann, H., and Roelfsema, P.R. The role of attention in figure-ground segregation in areas V1 and V4 of the visual cortex. Neuron 75 (2012) 143-156. [abstract]

 

Saab, A.S., Neumeyer, A., Jahn, H.M., Cupido, A., Simek, A.A.M., Boele, H.J., Scheller, A., Le Meur, K., Gotz, M., Monyer, H., Sprengel, R., Rubio, M.E., Deitmer, J.W., De Zeeuw, C.I., and Kirchhoff, F. Bergmann glial AMPA receptors are required for fine motor coordination. Science 337 (2012) 749-753. [abstract]

Hallerman, S., De Kock, C.P.J., Stuart, G.J., and Kole, M.H.P. State and location dependence of action potential metabolic cost in cortical pyramidal neurons. Nature Neuroscience 15 (2012) 1007-1014. [abstract]

  

Self, M.W., Kooijmans, R.N., Super, H., Lamme, V.A., and Roelfsema, P.R. Different glutamate receptors convey feedforward and recurrent processing in macaque V1. PNAS 109 (2012) 11031-11036. [abstract]

 

Astill, R.G., Van der Heijden, K.B., Van IJzendoorn, M.H., Van Someren E.J.W. Sleep, cognition, and behavioral problems in school-age children: a century of research meta-analyzed. Psychological Bulletin, in press. [abstract]

 

More publications 

Text/HTML

News

6 May 2013
  
Elly Hol receives k€300 funding from ZonMW (More Knowledge with Fewer Animals programme) for a project on human adult neural stem cells.
_________________________________
           

29 April 2013: Spinoza Centre:

The Spinoza Centre for Neuroimaging website has gone live. A button has been placed on web page of our institute. Please visit www.spinozacentre.nl to see what the Spinoza Centre is all about.
_________________________________
   

17 April 2013. In the news:     

Elly Hol on Alzheimer Research [pdf]
_________________________________

 

2 April 2013.
Recent paper of Joanna Korecka selected by the Media Outreach Program of IOS Press to be brought to the attention of the media.[press release]
_________________________________

 

27 February 2013.
Joost Verhaagen receives the Schellenberg Prize 2013 from the International Foundation for Research in Paraplegia.
_________________________________

14 February 2013.
Christiaan Levelt and Maarten Kamermans receive funding in the ALW Open Programme.
_________________________________

1 February 2013

Christian Lohmann receives a VICI grant from NWO.

_________________________________

26 January 2013. In the news:Joost Verhaagen and Martijn Malessy.

Progress in neural repair: from robotics to molecular neurosurgery. [pdf]

_________________________________

16 January 2013, Persbericht KNAW: Diepere slaap: sterkere verbindingen in de hersenen[persbericht]

_________________________________

15 January 2013, Press release ERC: The 3000th ERC grant went to the Social Brain Lab at the NIN[press release]Social Brain Lab - ERC (YouTube movie)

_________________________________

10 January 2013, Persbericht KNAW: Nederlands Herseninstituut is nieuwe naam voor NIN-KNAW[persbericht]

_________________________________

10 December 2012, Persbericht op Kennislink: Moleculen ontdekt die zenuwschade kunnen herstellen[persbericht]

_________________________________

Published: Handbook of Clinical Neurology, volume 109, Spinal Cord Injury. Editors: J. Verhaagen and J.W. McDonald.   Expected April 2013: Jij bent je brein.Authors: Dick Swaab and Jan Paul Schutten.


NINnews May 2012 
              

NINnews October 2011 

 

NINnews April2011

 

NINnews November2010 

 

NINnews June 2010

 

More

Events

29 May 2013, 11:30 h, Queridozaal ErasmusMC

Laurens Witter will defend his thesis entitled:
Whole cell recordings of the cerebellum in vivo.
_______________________________________

4 June 2013, 10:00 h, Agnietenkapel
   
Ji Liu will defend his thesis entitled:
  
The role of estrogen in hypothalamic regulation of hypothalamus-pituitary-adrenal axis activity, energy homeostasis and bone metabolism.


Gestart op 20 januari 2012
Groot nationaal Slaaponderzoek
bezoek de website en doe mee!

More