The Netherlands Institute for Neuroscience (NIN) carries out fundamental neuroscience research with special emphasis on the brain and the visual system. Our research focusses on development, plasticity and ageing and it is often linked to clinical research questions.


The scientific structure comprises three levels of biological complexity:

  • genetic and molecular approaches
  • cellular approaches and network function
  • system approaches


The research program is carried out in 20 research groups.
In addition, the NIN includes the Netherlands Brain Bank and participates in the Spinoza Centre for Neuroimaging


Scientific Director Pieter R. Roelfsema, PhD
Vice Director Chris I. de Zeeuw, PhD
Managing Director Ronald van der Neut, PhD




Recent Publications

Saiepour, M.H., Chakravarthy, S., Min, R., and Levelt, C.N. Competition and homeostasis of excitatory and inhibitory connectivity in the adult mouse visual cortex. Cerebral Cortex, in press.


Van Kerkoerle, T., Self, M.W., Dagnino, B., Gariel-Mathis, M.A., Poort, J., Van der Togt, C., and Roelfsema, P.R. Alpha and gamma oscillations characterize feedback and feedforward processing in monkey visual cortex. PNAS, in press.


Wang, F., Kessels, H.W., and Hu, H. The mouse that roared: neural mechanisms of social hierarchy. Trends in Neurosciences, in press. [abstract]


Springelkamp, H., Hohn, R., Mishra, A.,.....De Jong, P.T.V.M., ...Bergen, A.A.B., ....Van Duijn, C.M., and Hammond, C.J. Meta-analysis of genome-wide association studies identifies novel loci that influence cupping and the glaucomatous process. Nature Communications, in press.


Piantoni, G., Van der Werf, Y.D., Jensen, O., and Van Someren, E.J.W. Memory traces of long-range coordinated oscillations in the sleeping human brain. Human Brain Mapping, in press. [abstract]


Van den Heuvel, J.K., Furman, K., Gumbs, M.C., Eggels, L., Opland, D.M., Land, B.B., Kolk, S.M., Narayanan, N., Fliers, E., Kalsbeek, A., DiLeone, R.J., and La Fleur, S.E. Neuropeptide Y activity in the nucleus accumbens modulates feeding behavior and neuronal activity. Biological Psychiatry, in press. [abstract]


Raaphorst, J., Van Tol, M.J., Groot, P.F., Altena, E., Van der Werf, Y.D., Majoie, C.B., Van der Kooi, A.J., Van den Berg, L.H., Schmand, B., De Visser, M., and Veltman, D.J. Prefrontal involvement related to cognitive impairment in progressive muscular atrophy. Neurology, in press. [abstract]


Willuhn, I., Tose, A., Wanat, M.J., Hart, A.S., Hollon, N.G., Phillips, P.E., Schwarting, R.K., and Wohr, M. Phasic dopamine release in the nucleus accumbens in response to pro-social 50 kHz ultrasonic vocalizations in rats. Journal of Neuroscience 34 (2014) 10616-10623. [abstract]


Hahn, A., Kranz, G.S., Kublbock, M., Kaufmann, U., Ganger, S., Hummer, A., Seiger, R., Spies, M., Winkler, D., Kasper, S., Windischberger, C., Swaab, D.F., and Lanzenberger, R. Structural connectivity networks of transgender people. Cerebral Cortex, in press.  


Self, M.W., Lorteije, J.A., Vangeneugden, J., Van Beest, E.H., Grigore, M.E., Levelt, C.N., Heimel, J.A., and Roelfsema, P.R. Orientation-tuned surround suppression in mouse visual cortex. Journal of Neuroscience 34 (2014) 9290-9304. [abstract]


Orre, M., Kamphuis, W., Osborn, L.M., Jansen, A.H., Kooijman, L., Bossers, K., and Hol, E.M. Isolation of glia from Alzheimer's mice reveals inflammation and dysfunction. Neurobiology of Aging, in press. [abstract]


De Gruijl, J.R., Hoogland, T.M., and De Zeeuw, C.I. Behavioral correlates of complex spike synchrony in cerebellar microzones. Journal of Neuroscience 34 (2014) 8937-8947. [abstract]


Roelfsema, P.R., and Treue, S. Basic neuroscience research with nonhuman primates: a small but indispensable component of biomedical research. Neuron 82 (2014) 1200-1204. [abstract]


Cuadrado, E., Vanderver, A., Brown, K.J., Sandza, A., Takanohashi, A., Jansen, M.H., Anink, J., Herron, B., Orcesi, S., Olivieri, I., Rice, G.I., Aronica, E., Lebon, P., Crow, Y.J., Hol, E.M., and Kuijpers, T.W. Aicardi-Goutieres syndrome harbours abundant systemic and brain-reactive autoantibodies. Annals of the Rheumatic Diseases, in press. [abstract]


Clopath, C., Badura, A., De Zeeuw, C.I., and Brunel, N. A cerebellar learning model of vestibulo-ocular reflex adaptation in wild-type and mutant mice. Journal of Neuroscience 34 (2014) 7203-7215. [abstract]


Vroman, R., Klaassen, L.J., Howlett, L.J., Cenedese, V., Klooster, J., Sjoerdsma, T., and Kamermans, M. Extracellular ATP hydrolysis inhibits synaptic transmission by increasing pH buffering in the synaptic cleft. PLoS Biology 12 (2014) e1001864. [article]


More publications




17 September 2014

A grant of 150,000 euro was provided bij OC&W for the project 'a quantified reader'. Participants are: TNO, Nijgh&Ditmar, MKB, Arnon Grunberg and Ysbrand van der Werf

8 August 2014

Valeria Gazzola was granted a NARSAD young investigator grant to study whether changing brain activity in empathy related regions using tDCS will alter helping behaviour.

29 July 2014

A VENI grant was awarded to the group of Julie Bakker:


Elseline Hoekzema for the project The effects of pregnancy on the human brain.

29 July 2014

Two VENI grants were awarded to the group of Chris De Zeeuw:


Cathrin Canto for the project Memory mechanisms in the sleeping cerebellum and

Aleksandra Badura for the project The autistic cerebellum

18 June 2014

On May 1, 2014 De Stichting Physica appointed Maarten Kole special professor in the Biophysics of complex cellular systems. This chair is connected to the University of Utrecht.

21 May 2014
Chris De Zeeuw and Rainer Goebel are chosen as members of the Royal Academy of Arts and Sciences.

17 March 2014

Dick Swaab has been selected as winner of the 2014 ECNP Media Award.


NINnews December 2013

NINnews June 2013

NINnews May 2012

NINnews October 2011

NINnews April 2011

NINnews November 2010

NINnews June 2010




17 October 2014, 11.45 h, Aula VU, Amsterdam


Nitish Fagoe will defend his thesis entitled:


Adeno-associated viral vector-mediated delivery of transcription factors to promote axon regeneration.

24 October 2014, 10.00 h, Agnietenkapel Amsterdam


Martina Moeton will defend her thesis entitled:


The astrocytic cytoskeleton: unravelling the role of GFAPΔ.