Mission

Mission statement:


Architecture of the mind

Our mission is to understand how networks of neurons enable the cognitive functions of the brain, including consciousness, perception, movement, learning and social interaction, in health and disease.

The research program integrates three levels of biological complexity:
  • genetic and molecular approaches
  • cellular approaches and network function
  • system and behavioral approaches

The research program is carried out in 19 research groups. In addition, the NIN includes the Netherlands Brain Bank and participates in the Spinoza Centre for Neuroimaging

Scientific Director Pieter R. Roelfsema, PhD
Vice Director Chris I. de Zeeuw, PhD
Managing Director Ronald van der Neut, PhD

 

 

 

Recent Publications

Stargardt, A., Swaab, D.F., and Bossers, K. The storm before the quiet: neuronal hyperactivity and Aβ in the presymptomatic stages of Alzheimer's disease. Neurobiology of Aging, in press.

   

Kranz, G., Hahn, A., Kaufman, U., Kublbock, M., Hummer, A., Ganger, S., Seiger, R., Winkler, D., Swaab, D.F., Windischberger, C., Kasper, S., and Lanzenberger, R. White matter microstructure in transsexuals and controls investigated by diffusion tensor imaging. Journal of Neuroscience, in press.

     

Saiepour, M.H., Chakravarthy, S., Min, R., and Levelt, C.N. Competition and homeostasis of excitatory and inhibitory connectivity in the adult mouse visual cortex. Cerebral Cortex, in press.

      

Van Kerkoerle, T., Self, M.W., Dagnino, B., Gariel-Mathis, M.A., Poort, J., Van der Togt, C., and Roelfsema, P.R. Alpha and gamma oscillations characterize feedback and feedforward processing in monkey visual cortex. PNAS, in press.

    

Wang, F., Kessels, H.W., and Hu, H. The mouse that roared: neural mechanisms of social hierarchy. Trends in Neurosciences, in press. [abstract]

   

Springelkamp, H., Hohn, R., Mishra, A.,.....De Jong, P.T.V.M., ...Bergen, A.A.B., ....Van Duijn, C.M., and Hammond, C.J. Meta-analysis of genome-wide association studies identifies novel loci that influence cupping and the glaucomatous process. Nature Communications, in press.

       

Piantoni, G., Van der Werf, Y.D., Jensen, O., and Van Someren, E.J.W. Memory traces of long-range coordinated oscillations in the sleeping human brain. Human Brain Mapping, in press. [abstract]

                  

Van den Heuvel, J.K., Furman, K., Gumbs, M.C., Eggels, L., Opland, D.M., Land, B.B., Kolk, S.M., Narayanan, N., Fliers, E., Kalsbeek, A., DiLeone, R.J., and La Fleur, S.E. Neuropeptide Y activity in the nucleus accumbens modulates feeding behavior and neuronal activity. Biological Psychiatry, in press. [abstract]

     

Raaphorst, J., Van Tol, M.J., Groot, P.F., Altena, E., Van der Werf, Y.D., Majoie, C.B., Van der Kooi, A.J., Van den Berg, L.H., Schmand, B., De Visser, M., and Veltman, D.J. Prefrontal involvement related to cognitive impairment in progressive muscular atrophy. Neurology, in press. [abstract]

      

Willuhn, I., Tose, A., Wanat, M.J., Hart, A.S., Hollon, N.G., Phillips, P.E., Schwarting, R.K., and Wohr, M. Phasic dopamine release in the nucleus accumbens in response to pro-social 50 kHz ultrasonic vocalizations in rats. Journal of Neuroscience 34 (2014) 10616-10623. [abstract]

    

Hahn, A., Kranz, G.S., Kublbock, M., Kaufmann, U., Ganger, S., Hummer, A., Seiger, R., Spies, M., Winkler, D., Kasper, S., Windischberger, C., Swaab, D.F., and Lanzenberger, R. Structural connectivity networks of transgender people. Cerebral Cortex, in press.  

      

Self, M.W., Lorteije, J.A., Vangeneugden, J., Van Beest, E.H., Grigore, M.E., Levelt, C.N., Heimel, J.A., and Roelfsema, P.R. Orientation-tuned surround suppression in mouse visual cortex. Journal of Neuroscience 34 (2014) 9290-9304. [abstract]

 

Orre, M., Kamphuis, W., Osborn, L.M., Jansen, A.H., Kooijman, L., Bossers, K., and Hol, E.M. Isolation of glia from Alzheimer's mice reveals inflammation and dysfunction. Neurobiology of Aging, in press. [abstract]

   

De Gruijl, J.R., Hoogland, T.M., and De Zeeuw, C.I. Behavioral correlates of complex spike synchrony in cerebellar microzones. Journal of Neuroscience 34 (2014) 8937-8947. [abstract]

   

Roelfsema, P.R., and Treue, S. Basic neuroscience research with nonhuman primates: a small but indispensable component of biomedical research. Neuron 82 (2014) 1200-1204. [abstract]

   

Cuadrado, E., Vanderver, A., Brown, K.J., Sandza, A., Takanohashi, A., Jansen, M.H., Anink, J., Herron, B., Orcesi, S., Olivieri, I., Rice, G.I., Aronica, E., Lebon, P., Crow, Y.J., Hol, E.M., and Kuijpers, T.W. Aicardi-Goutieres syndrome harbours abundant systemic and brain-reactive autoantibodies. Annals of the Rheumatic Diseases, in press. [abstract]

   

Clopath, C., Badura, A., De Zeeuw, C.I., and Brunel, N. A cerebellar learning model of vestibulo-ocular reflex adaptation in wild-type and mutant mice. Journal of Neuroscience 34 (2014) 7203-7215. [abstract]

  

More publications

 

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News

18 October 2014

Dick Swaab wins the 2014 ECNP Media Award. The award will be presented at the welcome ceremony of the 27th ECNP Congress in Berlin.
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6 October 2014

In the program Memorabel, part of the Deltaplan Dementie, ZonMw granted 1.5 million euros to the project Learning to resist Alzheimer's disease, novel molecular mechanisms that protect neurons against amyloid-beta, by Joost Verhaagen, Guus Smit (VU) and Helmut Kessels.
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17 September 2014

A grant of 150,000 euro was provided bij OC&W for the project 'a quantified reader'. Participants are: TNO, Nijgh&Ditmar, MKB, Arnon Grunberg and Ysbrand van der Werf
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8 August 2014

Valeria Gazzola was granted a NARSAD young investigator grant to study whether changing brain activity in empathy related regions using tDCS will alter helping behaviour.
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29 July 2014

A VENI grant was awarded to the group of Julie Bakker:

  

Elseline Hoekzema for the project The effects of pregnancy on the human brain.
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29 July 2014

Two VENI grants were awarded to the group of Chris De Zeeuw:

    

Cathrin Canto for the project Memory mechanisms in the sleeping cerebellum and

    
Aleksandra Badura for the project The autistic cerebellum
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18 June 2014

On May 1, 2014 De Stichting Physica appointed Maarten Kole special professor in the Biophysics of complex cellular systems. This chair is connected to the University of Utrecht.





 

NINnews December 2013

NINnews June 2013

NINnews May 2012

NINnews October 2011

NINnews April 2011

NINnews November 2010

NINnews June 2010

 

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Events

24 October 2014, 10.00 h, Agnietenkapel, Amsterdam

 

Martina Moeton will defend her thesis entitled:

  

The astrocytic cytoskeleton: unravelling the role of GFAPΔ.
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4 November 2014, 14.00 h, Agnietenkapel, Amsterdam

   

Sarah Janssen will defend her thesis entitled:

   

Molecular mechanisms underlying primary open angle glaucoma.


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